Dasatinib (BMS-354825)

Name: Dasatinib (BMS-354825)
SKU: A10290
Price: 175 CNY
Rating: 5 (14 reviews)

目录号: A10290

Abl-Src 抑制剂

14 篇发表文献

Dasatinib（BMS-354825）是一种口服多效 BCR/ABL 和 Src 家族酪氨酸激酶抑制剂。Dasatinib 的主要靶点包括 BCR/ABL、Src、c-Kit、ephrin 受体以及其他几种酪氨酸激酶，但不包括 erbB 激酶，如 EGFR 或 Her2。

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Grouped product items
规格	价格	库存
10mg	¥175.00	现货
50mg	¥210.00	现货
100mg	¥315.00	现货
200mg	¥385.00	现货
500mg	¥630.00	现货
1g	¥910.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

Other Forms of Dasatinib (BMS-354825)

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Dasatinib (BMS-354825)发表的14篇文献

Hiroyasu Aoki, .et al. , Cell Rep, 2024, Mar 26;43(3):113887 PMID: 38458195

Hiroto Kataoka, .et al. , Anal Biochem, 2023, Oct 1;678 PMID: 37541642

Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138

Chihiro Motozono, .et al. , Nat Commun, 2022, Sep 21;13(1):5440 PMID: 36130929

Aya Hasan Alshammari, .et al. , Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812

Adi Jacob Berger, .et al. , Nat Cancer, 2021, 2, 1055-1070 PMID: 35121883

David E J Klawon, .et al. , J Exp Med, 2021, Jun 7;218(6) PMID: 33914024

Reiko Watanabe, .et al. , J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967

Li Li, .et al. , Leukemia Res, 2019, 78:12-20 PMID: 30660961

Sano T, .et al. , Am J Pathol, 2018, Nov;188(11):2564-2573 PMID: 30121259

Ines Peschel, .et al. , Haematologica, 2017, Aug; 102(8): 1378-1389 PMID: 28522571

Brittany M. Duggan, .et al. , Sci Rep, 2017, 7: 1578 PMID: 28484277

John D. Leonard, .et al. , Immunity, 2017, Jul 18; 47(1): 107-117.e8 PMID: 28709804

Fujita KI, .et al. , J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358

生物活性

Discription

Dasatinib (BMS-354825) is an oral multi- BCR/ABL and Src family tyrosine kinase inhibitor. The main targets of dasatinib, are BCR/ABL, Src, c-Kit, ephrin receptors, and several other tyrosine kinases, but not erbB kinases such as EGFR or Her2.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10290
分子式	C22H26ClN7O2S
分子量	488
CAS号	302962-49-8
SMILES	CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C
其他名称	Sprycel
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	84 mg/mL (172.12 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.49 mL	102.46 mL	204.92 mL
0.5 mM	4.1 mL	20.49 mL	40.98 mL
1 mM	2.05 mL	10.25 mL	20.49 mL
5 mM	0.41 mL	2.05 mL	4.1 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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