Dasatinib (BMS-354825)

Name: Dasatinib (BMS-354825)
SKU: A10290

目录号: A10290

Abl-Src 抑制剂

Product Citations (10)

Dasatinib (BMS-354825) Chemical Structure

CAS NO. 302962-49-8

Dasatinib (BMS-354825)是一种口服多BCR/ABL和Src家族酪氨酸激酶抑制剂。Dasatinib (BMS-354825)的主要靶标是BCR/ABL，Src，c-Kit，ephrin受体和其他几种酪氨酸激酶，但不是erbB激酶，例如EGFR或Her2。

库存：现货

规格	价格	数量
100 mg	￥ 385.00
200 mg	￥ 490.00
10mM * 1mL in DMSO	￥ 420.00

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产品仅用于科学研究，不针对患者销售，望谅解.

产品详情

生物活性

靶点信息

Abl (Cell-free assay)	Src (Cell-free assay)	c-Kit (D816V) (Cell-free assay)	c-Kit (wt) (Cell-free assay)
0.6 nM	0.8 nM	37 nM	79 nM

溶解度 *

In vitro (25°C)	DMSO	84 mg/mL (172.12 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.49 mL	102.46 mL	204.92 mL
0.5 mM	4.1 mL	20.49 mL	40.98 mL
1 mM	2.05 mL	10.25 mL	20.49 mL
5 mM	0.41 mL	2.05 mL	4.1 mL

*The above data is based on the productmolecular weight 488.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10290
作用机制	Inhibitor (抑制剂)
M. Wt	488.0
Formula	C22H26ClN7O2S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	302962-49-8
Synonyms	Sprycel
SMILES	CC1=C(C(=CC=C1)Cl)NC(=O)C2=CN=C(S2)NC3=NC(=NC(=C3)N4CCN(CC4)CCO)C