dBET6

Name: dBET6
SKU: A20110
Price: 280 CNY
Rating: 5 (288 reviews)

目录号: A20110

BET degrader

dBET6 是一种基于 PROTAC 的 BET 降解剂，具有高效、选择性和细胞渗透性，IC50 为 14 nM，并具有抗肿瘤活性。

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Grouped product items
规格	价格	库存
1mg	¥280.00	现货
5mg	¥630.00	现货
10mg	¥1,155.00	现货
25mg	¥2,205.00	现货
50mg	¥3,570.00	现货
100mg	¥5,180.00	现货
200mg	¥6,580.00	现货
500mg	¥9,625.00	现货
*10mM 1mL in DMSO**	¥1,050.00	现货
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Data Sheet

SDS

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生物活性

Discription

dBET6 is a highly potent, selective and cell-permeable degrader of BET based on PROTAC, with an IC50 of 14 nM, and has antitumor activity.

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A20110
分子式	C42H45ClN8O7S
分子量	841.37
CAS号	1950634-92-0
SMILES	O=C(NCCCCCCCCNC(COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)=O)C[C@H]4C5=NN=C(C)N5C6=C(C(C)=C(C)S6)C(C7=CC=C(Cl)C=C7)=N4
其他名称	dBET 6, dBET-6
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	96 mg/mL (114.1 mM)
	Water	Insoluble
	Ethanol	40 mg/mL (47.53 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	11.89 mL	59.43 mL	118.85 mL
0.5 mM	2.38 mL	11.89 mL	23.77 mL
1 mM	1.19 mL	5.94 mL	11.89 mL
5 mM	0.24 mL	1.19 mL	2.38 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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