DC1SMe
目录号: A20181
DNA alkylator
DC1Sme,一种DC1的衍生物,对Ramos、Namalwa、HL60/s和COLO 205癌细胞的IC50值分别为22 pM、10 pM、32 pM和250 pM。DC1是CC-1065的简化类似物,是一种用于癌症靶向治疗的细胞毒性DNA烷化剂的抗体偶联物。
DNA alkylator
Discription | DC1Sme, a DC1 derivative, exhibits IC50 values of 22 pM, 10 pM, 32 pM and 250 pM for Ramos, Namalwa, HL60/s and COLO 205 cancer cells, respectively. DC1, a simplified analogue of CC-1065, is an antibody conjugate of cytotoxic DNA alkylators for the targeted treatment of cancer. | |||||
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Cell Research |
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目录号 | A20181 |
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分子式 | C35H30ClN5O4S2 |
分子量 | 684.23 |
CAS号 | 501666-85-9 |
SMILES | O=C(C(N1)=CC2=C1C=CC(NC(CCSSC)=O)=C2)NC3=CC4=C(NC(C(N5C[C@@H](CCl)C6=C5C=C(O)C7=CC=CC=C67)=O)=C4)C=C3 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2