产品详情

生物活性

Defactinib (VS-6063; PF-04554878) is a novel FAK inhibitor with potential antiangiogenic and antineoplastic activities.

溶解度 *

In vitro (25°C)	DMSO	Warmed: 5 mg/mL (9.79 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+50% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.59 mL	97.95 mL	195.89 mL
0.5 mM	3.92 mL	19.59 mL	39.18 mL
1 mM	1.96 mL	9.79 mL	19.59 mL
5 mM	0.39 mL	1.96 mL	3.92 mL

*The above data is based on the productmolecular weight 510.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A21958
作用机制	Inhibitor (抑制剂)
M. Wt	510.49
Formula	C20H21F3N8O3S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1073154-85-4
Synonyms	VS-6063, VS 6063, VS6063; PF-04554878, PF04554878, PF04554878
SMILES	O=C(NC)C1=CC=C(NC2=NC=C(C(F)(F)F)C(NCC3=NC=CN=C3N(C)S(=O)(C)=O)=N2)C=C1