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DG-172是一种口服活性强效PPARβ/δ反向激动剂 (IC50 = 26.9 nM)。DG-172在体外抑制小鼠成肌细胞中Angptl4基因的表达 (IC50 = 9.5 nM)。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.97 mL | 109.84 mL | 219.67 mL |
| 0.5 mM | 4.39 mL | 21.97 mL | 43.93 mL |
| 1 mM | 2.2 mL | 10.98 mL | 21.97 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.39 mL |
*The above data is based on the productmolecular weight 455.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16309 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 455.22 |
| Formula | C20H22BrCl2N3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1361504-77-9 |
| Synonyms | DG 172 dihydrochloride |
| SMILES | N#C/C(C1=CC=CC=C1Br)=C\C2=CC=C(N3CCN(C)CC3)C=C2.[H]Cl.[H]Cl |
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