Diclofenac sodium

Name: Diclofenac sodium
SKU: A10304

目录号: A10304

COX 抑制剂

Diclofenac sodium Chemical Structure

CAS NO. 15307-79-6

Diclofenac Sodium是一种非选择性的COX抑制剂，完整细胞中的COX-1和-2的IC50分别为0.5μg/ml和0.5μg/ml，作用于绵羊COX-1和COX-2， IC50分别为60和220 nM，用作非甾体类抗炎药（NSAID）来减轻疼痛和减轻疼痛肿胀发炎。

库存：现货

规格	价格	数量
500 mg	￥ 315.00
10mM * 1mL in DMSO	￥ 476.00

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生物活性

靶点信息

COX-1	COX-2
60 nM	200 nM

溶解度 *

In vitro	DMSO	54 mg/mL (169.74 mM)
	Water	12 mg/mL (37.71 mM)
	Ethanol	54 mg/mL (169.74 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.43 mL	157.17 mL	314.34 mL
0.5 mM	6.29 mL	31.43 mL	62.87 mL
1 mM	3.14 mL	15.72 mL	31.43 mL
5 mM	0.63 mL	3.14 mL	6.29 mL

*The above data is based on the productmolecular weight 318.13. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10304
作用机制	Inhibitor (抑制剂)
M. Wt	318.13
Formula	C14H10Cl2NNaO2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	15307-79-6
SMILES	C1=CC=C(C(=C1)CC(=O)[O-])NC2=C(C=CC=C2Cl)Cl.[Na+]