Dinaciclib (SCH 727965)

Name: Dinaciclib (SCH 727965)
SKU: A11129
Price: 280 CNY
Rating: 5 (5 reviews)

目录号: A11129

CDK 抑制剂

5 篇发表文献

Dinaciclib (SCH 727965) 是一种强效且选择性的环依赖性激酶（CDK）抑制剂，选择性抑制 CDK1、CDK2、CDK5 和 CDK9，其 IC50 值分别为 3、1、1 和 4 nM。

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Grouped product items
规格	价格	库存
2mg	¥280.00	现货
5mg	¥455.00	现货
10mg	¥805.00	现货
25mg	¥1,645.00	现货
50mg	¥2,625.00	现货
100mg	¥4,795.00	现货
*10mM 1mL in DMSO**	¥490.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Dinaciclib (SCH 727965)发表的5篇文献

Vineeta Teotia, .et al. , ACS Omega, 2024, Sep 13;9(38):39873-39892 PMID: 39346877

Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138

Sepideh Izadi, .et al. , Pharm Res, 2020, Sep 17;37(10):196 PMID: 32944844

Shahin Hallaj, .et al. , Life Sci, 2020, Jul 26 PMID: 32726663

Washio I, .et al. , Drug Metab Dispos, 2018, Mar;46(3):214-222 PMID: 29246888

生物活性

Discription

Dinaciclib (SCH 727965) is a potent and selective cyclin-dependent kinase (CDK) inhibitor, selectively inhibiting CDK1, CDK2, CDK5 and CDK9 with IC50 values of 3, 1, 1 and 4 nM respectively.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11129
分子式	C21H28N6O2
分子量	396.5
CAS号	779353-01-4
SMILES	CCC1=C2N=C(C=C(N2N=C1)NCC3=C[N+](=CC=C3)[O-])N4CCCC[C@H]4CCO
其他名称	SCH727965, SCH-727965
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	Warmed: 22 mg/mL (55.48 mM)
	Water	Insoluble
	Ethanol	Warmed: 7 mg/mL (17.65 mM)
In vivo	2% DMSO+30% PEG 300+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.22 mL	126.1 mL	252.21 mL
0.5 mM	5.04 mL	25.22 mL	50.44 mL
1 mM	2.52 mL	12.61 mL	25.22 mL
5 mM	0.5 mL	2.52 mL	5.04 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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