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DMOG是HIF-PH的细胞渗透性竞争性抑制剂。它可在正常的氧气张力下（0.1至1 mM的浓度）稳定HIF-1α表达。
靶点信息
| HIF prolyl hydroxylase | ||||
| In vitro | DMSO | 33 mg/mL (188.42 mM) | |
| Water | 33 mg/mL (188.42 mM) | ||
| Ethanol | 33 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 57.1 mL | 285.49 mL | 570.97 mL |
| 0.5 mM | 11.42 mL | 57.1 mL | 114.19 mL |
| 1 mM | 5.71 mL | 28.55 mL | 57.1 mL |
| 5 mM | 1.14 mL | 5.71 mL | 11.42 mL |
*The above data is based on the productmolecular weight 175.14. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13998 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 175.14 |
| Formula | C6H9NO5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 89464-63-1 |
| Synonyms | Dimethyloxaloyl glycine |
| SMILES | COC(=O)CNC(=O)C(=O)OC |
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