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DNA Methyltransferases

DNA Methyltransferases

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Lomeguatrib

Catalog No. A12785
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MGMT 抑制剂

Lomeguatrib是O6-烷基鸟嘌呤-DNA-烷基转移酶的有效抑制剂。了解更多

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CM-272

Catalog No. A17173
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G9a/DNMT 抑制剂

CM-272是血液恶性肿瘤中针对G9a和DNMT的可逆双重小分子抑制剂。了解更多

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CM-579

Catalog No. A18692
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G9a/DNMT inhibitor

CM-579 is a first-in-class reversible, dual inhibitor of G9a and DNMT, with IC50 values of 16 nM, 32 nM for G9a and DNMT, respectively. Has potent in vitro cellular activity in a wide range of cancer cells. 了解更多

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6-Methyl-5-azacytidine

Catalog No. A13391
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DNMT inhibitor

6-Methyl-5-azacytidine is a potent DNMT inhibitor. 了解更多

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O6BTG-octylglucoside

Catalog No. A11432
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MGMT inhibitor

O6BTG-octylglucoside is a potent O6-methylguanine-DNAmethyl-transferase (MGMT) inhibitor, with IC50s of 32 nM in vitro (cell extracts) and 10 nM in HeLa S3 cells. 了解更多

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(-)-Epigallocatechin gallate

Catalog No. A10005
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Antioxidant, antiangiogenic, antitumor agent

(-)-Epigallocatechin gallate是一种从绿茶中分离出来的强效抗氧化剂多酚类黄酮。了解更多

Product Citations (4)

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- Wafa Dridi, .et al. Influence of polysaccharide concentration on polyphenol-polysaccharide interactions, Carbohydr Polym, 2021, 274:118670 PMID: 34702486
- A S D'Costa, .et al. Inhibition of starch digestion by flavonoids: Role of flavonoid-amylase binding kinetics, Food Chem, 2020, Oct 1;341(Pt 2):128256 PMID: 33035827
- Fenteany G, .et al. Multilevel structure-activity profiling reveals multiple green tea compound families that each modulate ubiquitin-activating enzyme and ubiquitination by a distinct mechanism, Sci Rep, 2019, Sep 5;9(1):12801 PMID: 31488855
- LiliSun, .et al. Comparative Effect of Black, Green, Oolong and White Tea Intake on Body Weight Gain and Bile Acid Metabolism, Nutrition, 2019, pii:S0899-9007(18)31140-7
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Decitabine

Catalog No. A10292
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DNA Methyltransferase 抑制剂

Decitabine是一种次甲基化剂，它通过抑制DNA甲基转移酶来使DNA次甲基化。了解更多

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- Borbala Szabo, .et al. Aspirin mediates its antitumoral effect through inhibiting PTTG1 in pituitary adenoma, J Clin Endocrinol Metab, 2022, Sep 5;dgac496 PMID: 36059148
- Sangni Qian, .et al. Hypermethylation of tumor suppressor lncRNA MEF2C-AS1 frequently happened in patients at all stages of colorectal carcinogenesis, Clin Epigenetics, 2022, Sep 5;14(1):111 PMID: 36064442
- Borb??la Szab??, .et al. Demethylation status of somatic DNA extracted from pituitary neuroendocrine tumors indicates proliferative behavior, J Clin Endocrinol Metab, 2020, Jun 1;105(6):dgaa156 PMID: 32232382
- Bracha Shraibman, .et al. Human Leukocyte Antigen (HLA) Peptides Derived from Tumor Antigens Induced by Inhibition of DNA Methylation for Development of Drug-facilitated Immunotherapy, Mol Cell Proteomics, 2016, Sep; 15(9): 3058-3070 PMID: 27412690
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Azacitidine(Vidaza)

Catalog No. A10105
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DNMT 抑制剂

Azacitidine (Vidaza)是DNA和RNA中使用的胞嘧啶核苷的化学类似物，主要用于治疗骨髓增生异常综合症（MDS）。了解更多

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SGI-110 (Guadecitabine)

Catalog No. A12744
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DNMT 抑制剂

SGI-110 (Guadecitabine)是第二代DNA次甲基化剂。了解更多

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SGI 1027

Catalog No. A14120
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DNMT 抑制剂

SGI 1027是DNMT抑制剂，对DNMT1，DNMT3A和DNMT3B的IC50分别为6、8、7.5 uM。了解更多

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Procainamide HCl

Catalog No. A14240
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Sodium channel blocker/DNMT 抑制剂

Procainamide HCl是钠通道阻滞剂，又是DNA甲基转移酶抑制剂。了解更多

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RG108

Catalog No. A13054
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DNA methyltransferase 抑制剂

RG108是DNA甲基转移酶的非核苷抑制剂，IC50为115 nM。了解更多

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O6-Benzylguanine

Catalog No. A13706
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MGMT 抑制剂

O6-Benzylguanine是DNA烷基转移酶的有效底物和有效灭活剂。O6-苄基鸟嘌呤是MGMT的抑制剂。了解更多

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Nanaomycin A

Catalog No. A13477
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DNMT3B 抑制剂

Nanaomycin A是DNA甲基转移酶3B（DNMT3B）的选择性抑制剂，IC50值为500 nM。了解更多

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