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DNA, RNA Synthesis

DNA, RNA Synthesis

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Azithromycin (Zithromax)

Catalog No. A11803
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Azithromycin (Zithromax)是一种氮杂内酯类抗生素，可抑制革兰氏阴性细菌（如流感嗜血杆菌）的生长。了解更多

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- T Azuma ,etc. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents. Science of The Total Environment, 2016, 548-549:189-97..
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Bleomycin hydrochloride

Catalog No. A12773
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Bleomycin hydrochloride是一种诱导细胞凋亡的抗肿瘤抗生素。了解更多

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- QX Ou ,etc. Mechanisms of inactivation of Candida humilis and Saccharomyces cerevisiae by pulsed electric fields. Bioelectrochemistry, 2016, pii: S1567-5394(16)30257-2..
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Epirubicin

Catalog No. A12409
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Topoisomerase 抑制剂

Epirubicin是一种细胞可渗透的抗肿瘤抗生素。阿霉素的立体异构体，其心脏毒性降低。表柔比星的抗肿瘤作用是通过靶向和抑制Topo II（拓扑异构酶II）来介导的。了解更多

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- Xiu-wu Pan, .et al. Icaritin acts synergistically with epirubicin to suppress bladder cancer growth through inhibition of autophagy, Oncol Rep, 2016, Jan;35(1):334-42 PMID: 26496799
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INNO-206 (Aldoxorubicin)

Catalog No. A12326
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INNO-206 (Aldoxorubicin)是蒽环类抗生素阿霉素(DOXO-EMCH)的6-马来酰亚胺基腙衍生物前药，具有抗肿瘤活性。了解更多

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- Jingjing Ding, .et al. Self-Activatable Photo-Extracellular Vesicle for Synergistic Trimodal Anticancer Therapy, Adv Mater, 2021, Feb;33(7):e2005562 PMID: 33432702
- Dos Santos Câmara AL, .et al. Acid-sensitive lipidated doxorubicin prodrug entrapped in nanoemulsion impairs lung tumor metastasis in a breast cancer model, Nanomedicine (Lond), 2017, Aug;12(15):1751-1765 PMID: 28703043
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Tegafur

Catalog No. A10407
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DNA/RNA Synthesis 抑制剂

Tegafur是一种用于治疗癌症的化疗药物5-FU前药，是替加氟尿嘧啶的一种成分。了解更多

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- Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
- Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
- Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347
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RK-33

Catalog No. A16194
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DDX3 抑制剂

RK-33是有效的选择性DDX3抑制剂。RK-33与DDX3结合并取消其活性。了解更多

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- Yang SNY, .et al. RK-33 Is a Broad-Spectrum Antiviral Agent That Targets DEAD-Box RNA Helicase DDX3X, Cells, 2020, Jan 9;9(1). PMID: 31936642
- Zhang S, .et al. Nuclear bodies formed by polyQ-ataxin-1 protein are liquid RNA/protein droplets with tunable dynamics, Sci Rep, 2020, Jan 31;10(1):1557 PMID: 32005838
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Cycloheximide (Actidione)

Catalog No. A10036
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Protein Synthesis 抑制剂

Cycloheximide (Actidione)用作选择性抗生素。它抑制腐菌真菌真核生物的蛋白质合成(DNA依赖性RNA)。通过与80S核糖体结合而对皮肤真菌和系统性真菌无效。了解更多

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- Ke Chen, .et al. Junction plakoglobin regulates and destabilizes HIF2α to inhibit tumorigenesis of renal cell carcinoma, Cancer Commun (Lond), 2021, Apr; 41(4): 316-332 PMID: 33591636
- Zhiyuan Qin, .et al. miR-224-5p Contained in Urinary Extracellular Vesicles Regulates PD-L1 Expression by Inhibiting Cyclin D1 in Renal Cell Carcinoma Cells, Cancers (Basel), 2021, Feb 4;13(4):618 PMID: 33557163
- Hua Xu, .et al. Preclinical Study Using ABT263 to Increase Enzalutamide Sensitivity to Suppress Prostate Cancer Progression Via Targeting BCL2/ROS/USP26 Axis Through Altering ARv7 Protein Degradation, Cancers (Basel), 2020, Apr; 12(4): 831 PMID: 32235588
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Bleomycin

Catalog No. A14378
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Bleomycin是由Verticillus verticillus细菌产生的糖肽抗生素。它通过诱导DNA链断裂而起作用。了解更多

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- Ou QX, .et al. Mechanisms of inactivation of Candida humilis and Saccharomyces cerevisiae by pulsed electric fields, Bioelectrochemistry, 2017, Jun;115:47-55 PMID: 28063751
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Oxaliplatin (Eloxatin)

Catalog No. A10346
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DNA/RNA Synthesis 抑制剂

Oxaliplatin (Eloxatin)是一种DNA/RNA Synthesis抑制剂，具有抗结肠癌的抗肿瘤活性。了解更多

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- Mohamed Elbadawy, .et al. Anti-cancer activity of amorphous curcumin preparation in patient-derived colorectal cancer organoids, Biomed Pharmacother, 2021, Oct;142:112043 PMID: 34411919
- Tatsuya Usui, .et al. Hedgehog Signals Mediate Anti-Cancer Drug Resistance in Three-Dimensional Primary Colorectal Cancer Organoid Culture, Int J Mol Sci, 2018, Apr; 19(4): 1098 PMID: 29642386
- Shimokawa M, .et al. Visualization and targeting of LGR5+ human colon cancer stem cells, Nature, 2017, May 11;545(7653):187-192 PMID: 28355176
- Eri Takiguchi, .et al. Growth inhibitory effect of the Src inhibitor dasatinib in combination with anticancer agents on uterine cervical adenocarcinoma cells, Exp Ther Med, 2017, Nov; 14(5): 4293-4299 PMID: 29067110
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Clofarabine

Catalog No. A10228
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DNA/RNA Synthesis 抑制剂

Clofarabine具有抗肿瘤活性的第二代嘌呤核苷类似物。了解更多

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- Xie J, .et al. Optimization of a clofarabine-based drug combination regimen for the preclinical evaluation of pediatric acute lymphoblastic leukemia, Pediatr Blood Cancer, 2019, Dec 25:e28133 PMID: 31876116
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Clafen (Cyclophosphamide)

Catalog No. A10224
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Clafen (Cyclophosphamide)是氮芥芥烷化剂。烷基化剂将烷基（CnH2n+1）加至DNA。它在咪唑环的7个氮原子处将烷基连接到DNA的鸟嘌呤碱基。了解更多

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- Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
- Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
- Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347
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Cisplatin

Catalog No. A10221
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Cisplatin是一种无机铂络合物，在肿瘤细胞中能够通过形成DNA加合物抑制 DNA synthesis。建议使用DMF溶解，而不是DMSO。了解更多

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- RUI-NING LIANG, .et al. Kidney mesenchymal stem cells alleviate cisplatin-induced kidney injury and apoptosis in rats, Research Square, 2022, July 6th
- Wei Zeng, .et al. Lidocaine suppresses the malignant behavior of gastric cancer cells via the c-Met/c-Src pathway, Exp Ther Med, 2021, May; 21(5): 424 PMID: 33747163
- Yi-Ru Pan, .et al. ATM Inhibitor Suppresses Gemcitabine-Resistant BTC Growth in a Polymerase θ Deficiency-Dependent Manner, Biomolecules, 2020, Nov 9;10(11):1529 PMID: 33182492
- Amnah Alshangiti, .et al. The dietary flavonoid isoliquiritigenin is a potent cytotoxin for human neuroblastoma cells, Neuronal Signal, 2019, 2019
- Calhelha RC, .et al. Mathematical models of cytotoxic effects in endpoint tumor cell line assays: critical assessment of the application of a single parametric value as a standard criterion to quantify the dose-response effects and new unexplored proposal formats, Analyst, 2017, Oct 23;142(21):4124-4141 PMID: 28991301
- Pi-Lin Sung, .et al. Periostin in tumor microenvironment is associated with poor prognosis and platinum resistance in epithelial ovarian carcinoma, Oncotarget, 2016, Jan 26; 7(4): 4036-4047 PMID: 26716408
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YK 4-279

Catalog No. A11612
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RHA 抑制剂

YK 4-279是与致癌转录因子EWS-FLI1结合的RNA解旋酶A（RHA）抑制剂。了解更多

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- Christopher M Schafer, .et al. An inhibitor of endothelial ETS transcription factors promotes physiologic and therapeutic vessel regression, Proc Natl Acad Sci U S A, 2020, Oct 20;117(42):26494-26502 PMID: 33020273
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Carboplatin

Catalog No. A10182
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Carboplatin是一种化学疗法药物，可用于治疗某些形式的癌症（主要是卵巢癌，肺癌，头颈癌）。顺铂和卡铂以及奥沙利铂与DNA相互作用，类似于烷基化剂的作用机理。了解更多

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- Jianwei Dou, .et al. Development and evaluation of poly adenosine 5'-diphosphate-ribose polymerase 1 immobilization-based receptor chromatography, J Sep Sci, 2020, Dec 4 PMID: 33275824
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CX-5461

Catalog No. A11065
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DNA/RNA Synthesis 抑制剂

CX-5461是RNA聚合酶I（Pol I）的一流的非遗传毒性小分子靶向抑制剂，可激活p53途径而不会引起DNA损伤。了解更多

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- Taro Mannena, .et al. Distinct RNA polymerase transcripts direct the assembly of phase-separated DBC1 nuclear bodies in different cell lines, Mol Biol Cell, 2021, 32:ar33, 1?C11 PMID: 34495685
- Shuichiro Okamoto, .et al. The rRNA synthesis inhibitor CX-5461 may induce autophagy that inhibits anticancer drug-induced cell damage to leukemia cells, Biosci Biotechnol Biochem, 2020, Aug 15;1-8 PMID: 32799625
- Ahmed Abdullah Ahmed, .et al. A G-quadruplex-binding compound shows potent activity in human gemcitabine-resistant pancreatic cancer cells, Sci Rep, 2020, 10: 12192 PMID: 32699225
- Abed Saady, .et al. Applying styryl quinolinium fluorescent probes for imaging of ribosomal RNA in living cells, Dyes Pigm, 2020, 174: 107986
- Jackobel AJ, .et al. DNA binding preferences of S. cerevisiae RNA polymerase I Core Factor reveal a preference for the GC-minor groove and a conserved binding mechanism, Biochim Biophys Acta Gene Regul Mech, 2019, Aug 2:194408 PMID: 31382053
- Hiroaki Suzuki, .et al. The proline-arginine repeat protein linked to C9-ALS/FTD causes neuronal toxicity by inhibiting the DEAD-box RNA helicase-mediated ribosome biogenesi, Cell Death Dis, 2018, Oct; 9(10): 975 PMID: 30250194
- Anastasia Gelgor, .et al. Nucleolar stress enhances lytic reactivation of the Kaposi??s sarcoma-associated herpesvirus, Oncotarget, 2018, Mar 2; 9(17): 13822-13833 PMID: 29568397
- Wang ZF, .et al. The Hairpin Form of r(G4C2)exp in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules, Cell Chem Biol, 2018, Nov 29. pii: S2451-9456(18)30378-7 PMID: 30503283
- Yuko Fujiwara, .et al. A Nucleolar Stress-Specific p53-miR-101 Molecular Circuit Functions as an Intrinsic Tumor-Suppressor Network, EBioMedicine, 2018, Jul; 33: 33-48 PMID: 30049386
- Maïmouna Coura Kone, .et al. Three-Dimensional Distribution of UBF and Nopp140 in Relationship to Ribosomal DNA Transcription During Mouse Preimplantation Development, Biol Reprod, 2016, Apr;94(4):95, 1-12 PMID: 26984997
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Cidofovir (Vistide)

Catalog No. A10214
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DNA/RNA Synthesis 抑制剂

Cidofovir (Vistide)通过选择性抑制病毒DNA的合成而抑制病毒复制。了解更多

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- Adhikary A, .et al. π-Radical to σ-Radical Tautomerization in One-Electron-Oxidized 1-Methylcytosine and Its Analogs, J Phys Chem B, 2015, Sep 3;119(35):11496-505 PMID: 26237072
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Gemcitabine HCl (Gemzar)

Catalog No. A10423
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DNA/RNA Synthesis 抑制剂

Gemcitabine HCl (Gemzar)是一种DNA synthesis抑制剂，作用于PANC1，MIAPaCa2，BxPC3和Capan2细胞，通过在癌细胞dna复制过程中取代核酸的一个组成部分，防止肿瘤生长。了解更多

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- G. R. Iglesias, .et al. Hyperthermia-Triggered Gemcitabine Release from Polymer-Coated Magnetite Nanoparticles, Polymers, 2018, 10(3), 269
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Fluorouracil (Adrucil)

Catalog No. A10042
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DNA and RNA synthesis 抑制剂

Fluorouracil (Adrucil)是一种是DNA/RNA合成抑制剂，通过不可逆地抑制胸苷酸合酶起作用。了解更多

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- T Hoshiba ,etc. Decellularized matrices as in vitro models of extracellular matrix in tumor tissues at different malignant levels: Mechanism of 5-fluorouracil resistance in colorectal tumor cells. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research, 2016, 1863(11), 2749-2757.
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Bleomycin sulfate

Catalog No. A10152
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DNA/RNA Synthesis 抑制剂

Bleomycin Sulfate硫酸博来霉素是一种糖肽类抗生素，也是一种鳞状细胞癌(SCC)抗癌剂。了解更多

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- Mai Kanemaru, .et al. Nanoparticle-mediated local delivery of pioglitazone attenuates bleomycin-induced skin fibrosis, J Dermatol Sci, 2018, Jan;93(1):41-49 PMID: 30655107
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Daptomycin

Catalog No. A10289
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DNA/RNA Synthesis 抑制剂

Daptomycin是一种脂肽抗生素，用于治疗由革兰氏阳性生物体引起的某些感染。了解更多

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- Viktoria Lazar, .et al. Antibiotic combinations reduce Staphylococcus aureus clearance, Nature, 2022, 610: 540-546 PMID: 36198788
- Shigeru Fujimura, .et al. Antimicrobial efficacy of combined clarithromycin plus daptomycin against biofilms-formed methicillin-resistant Staphylococcus aureus on titanium medical devices., J Infect Chemother., 2015, Oct;21(10):756-9 PMID: 26162777
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4EGI-1

Catalog No. A14199
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eIF4E/eIF4G 抑制剂

4EGI-1是一种竞争性eIF4E/eIF4G相互作用抑制剂，KD值 25 uM。了解更多

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CRT0044876

Catalog No. A14304
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APE1 抑制剂

CRT0044876是一种有效的选择性APE1抑制剂，IC50约为3μM。了解更多

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SCR7

Catalog No. A15447
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DNA ligase IV 抑制剂

SCR7是一种特定的DNA Ligase IV抑制剂。SCR7通过激活p53介导的细胞凋亡来抑制多种细胞类型中双链断裂的末端连接，从而导致肿瘤消退。了解更多

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TAS-102

Catalog No. A15533
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Trifluridine-tipiracil hydrochloride mixture

TAS-102是一种生物利用的联合剂，由细胞毒性嘧啶类似物三氟吡啶（5-三氟-2α-脱氧胸苷或TFT）和胸苷磷酸化酶抑制剂（TPI）替吡西酯盐酸盐组成，摩尔比为1.0：0.5（TFT ：TPI），具有潜在的抗肿瘤活性。了解更多

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Mitomycin C

Catalog No. A11491
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DNA synthesis 抑制剂

Mitomycin C是一种DNA交联剂，可抑制DNA合成并诱导多种细胞凋亡。了解更多

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L189

Catalog No. A15790
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DNA Ligase 抑制剂

L189是新型人类DNA连接酶抑制剂，可抑制hLigI/III/IV，IC50为5/9/5μM。了解更多

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E3330

Catalog No. A14440
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APE1 Redox 抑制剂

E3330是有效的选择性APE1（Ref-1）抑制剂，可抑制NF-κBDNA结合活性。了解更多

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6-Mercaptopurine Monohydrate

Catalog No. A15898
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de novo purine synthesis 抑制剂

6-Mercaptopurine Monohydrate是一种广泛使用的抗白血病药物和免疫抑制药物，通过将硫嘌呤甲基转移酶代谢物掺入DNA和RNA来抑制嘌呤从头合成。了解更多

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Trifluridine

Catalog No. A10948
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Trifluridine 是一种抗疱疹病毒抗病毒药，主要用于眼睛。了解更多

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L67

Catalog No. A15978
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DNA ligases 抑制剂

L67是DNA连接酶抑制剂。L67抑制DNA连接酶I和III。L67是关于刻痕DNA的简单竞争性抑制剂。了解更多

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Saccharin 1-methylimidazole

Catalog No. A16114
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DNA and RNA synthesis activator

Saccharin 1-methylimidazole被认为是DNA和RNA合成的通用活化剂。了解更多

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AN2718

Catalog No. A16203
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RNA synthetase 抑制剂

AN2718是一种新型的含硼小分子，可抑制必需的蛋白质合成酶，亮氨酰转移RNA合成酶或LeuRS。了解更多

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Chebulinic acid

Catalog No. A16208
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Chebulinic acid是结核分枝杆菌DNA促旋酶的有效天然抑制剂，也可以抑制SMAD-3磷酸化，抑制H+K+-ATPase活性。了解更多

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Tubercidin

Catalog No. A13285
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Tubercidin是一种腺苷类似物，是一种从结核链霉菌获得的抗生素。了解更多

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MB-7133

Catalog No. A22007
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DNA synthesis inhibitor

MB-7133 is a DNA synthesis inhibitor. 了解更多

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CCT239065

Catalog No. A11147
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DNA, RNA Synthesis 抑制剂

CCT239065是一种突变蛋白激酶抑制剂，可抑制癌细胞中V600EBRAF下游的信号传导，阻断DNA合成并抑制增殖。了解更多

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NSC-207895 (XI-006)

Catalog No. A11179
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MDMX 抑制剂

NSC-207895 (XI-006)是细胞可渗透的苯并呋喃化合物，可通过抑制MDMX启动子转录活性（IC50 = 2.5 ?M，下调MCF-7，LNCaP和A549细胞中的p53负调节剂MDMX蛋白水平（1至10 ?M，持续16至24 h）），导致增强的p53稳定和激活。了解更多

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Nelarabine (Arranon)

Catalog No. A10632
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Nelarabine是一种嘌呤核苷类似物，可转化为其相应的阿拉伯糖基鸟嘌呤核苷酸三磷酸（araGTP），从而抑制DNA合成和细胞毒性，IC50为0.067-2.15 μM。了解更多

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Fludarabine Phosphate (Fludara)

Catalog No. A10395
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Fludarabine Phosphate (Fludara)是一种用于治疗血液恶性肿瘤(血细胞癌，如白血病和淋巴瘤)的化疗药物。氟达拉滨通过干扰核糖核苷酸还原酶和dna聚合酶来抑制DNA合成。它对分裂细胞和静止细胞都有活性。了解更多

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Floxuridine

Catalog No. A10392
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DNA/RNA Synthesis 抑制剂

Floxuridine是一种抗肿瘤药，属于抗代谢物，是一种MDCK/PEPT1抑制剂。了解更多

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Dacarbazine

Catalog No. A10281
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Dacarbazine是一种用于治疗各种癌症的抗肿瘤化学治疗药物。Dacarbazine是烷基化剂类别的成员，其通过向其DNA中添加烷基（CnH2n+1）来破坏癌细胞。了解更多

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Lincomycin hydrochloride (U-10149A)

Catalog No. A10532
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Lincomycin hydrochloride是Lincomycin的一水盐，是从林肯链霉菌中分离的林肯酰胺抗生素，据报道其抑制细菌蛋白质合成并依赖于浓度。了解更多

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Lomustine (CeeNU)

Catalog No. A10535
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Lomustine是一种烷基化亚硝脲化合物，具有类似于卡莫司汀的抗肿瘤活性，可引起DNA间交联。了解更多

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Mercaptopurine

Catalog No. A10568
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Mercaptopurine已显示出干扰DNA和RNA合成并引起从头嘌呤合成的抑制。了解更多

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Mizoribine

Catalog No. A10597
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Mizoribine是一种咪唑核苷免疫抑制剂，最早是从霉菌短柏中分离出来的，具有抗生素和细胞毒性作用。了解更多

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Adenine sulfate

Catalog No. A11804
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Adenine sulfate是腺嘌呤的硫酸盐形式，其是嘌呤衍生物和核碱基，在生物化学中具有多种作用。了解更多

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Thiostrepton

Catalog No. A12890
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natural cyclic oligopeptide antibiotic

Thiostrepton抑制细菌蛋白质合成的抗生素。通过GTPase延长因子G（EF-G），EF-TU（GTP）催化的aa-tRNA传递和起始因子2（IF-2）的活性来抑制mRNA-tRNA易位。抗肿瘤剂；通过下调FOXM1表达来诱导乳腺癌细胞的细胞周期停滞和凋亡。了解更多

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Apaziquone

Catalog No. A12406
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Apaziquone是吲哚醌生物还原前药和丝裂霉素C类似物，具有潜在的抗肿瘤和放射增敏活性。了解更多

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Ifosfamide

Catalog No. A10466
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Ifosfamide是一种细胞抑制剂，在结构上与环磷酰胺有关。了解更多

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Blasticidin S HCl

Catalog No. A14212
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Blasticidin S HCl是一种分离自gistreochromogenes链霉菌的核苷抗生素，并充当DNA和蛋白质合成抑制剂。了解更多

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