Domperidone

目录号: A10329
多潘立酮能够阻断多巴胺的作用。它对位于化学感受器触发区的 D2和D3多巴胺受体 有很强的亲和力,该区域位于血脑屏障之外,负责调节恶心和呕吐(位于第四脑室底部和菱形窝的后颅窝区)。
Grouped product items
规格 价格 库存 数量
50mg
¥210.00
现货
100mg
¥315.00
现货
200mg
¥595.00
现货
500mg
¥980.00
现货
10mM * 1mL in DMSO
¥315.00
现货
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Adooq用户使用Domperidone发表的1篇文献
  • Reiko Watanabe, .et al. , J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
  • 生物活性
    Discription Domperidone blocks the action of dopamine. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which, among others, regulates nausea and vomiting (area postrema on the floor of the fourth ventricle and rhomboid fossa).
    Targets
    Target Value
    Cell Research
    Cell Line Type Value Description References
    产品信息
    目录号 A10329
    分子式 C22H24ClN5O2
    分子量 425.91
    CAS号 57808-66-9
    SMILES C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O
    储存条件

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    溶解性数据
    In vitro DMSO 47 mg/mL (110.34 mM)
    Water Insoluble
    Ethanol 1 mg/mL (2.34 mM)
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 23.48 mL 117.4 mL 234.79 mL
    0.5 mM 4.7 mL 23.48 mL 46.96 mL
    1 mM 2.35 mL 11.74 mL 23.48 mL
    5 mM 0.47 mL 2.35 mL 4.7 mL
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