Doramapimod (BIRB-796)

Name: Doramapimod (BIRB-796)
SKU: A10148
Price: 175 CNY
Rating: 5 (4 reviews)

目录号: A10148

p38 MAPK 抑制剂

4 篇发表文献

Doramapimod（BIRB 796）是一种小分子抑制剂，针对 p38 MAPK 进行抑制，后者在调节促炎细胞因子的产生中起着关键作用。

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Grouped product items
规格	价格	库存
5mg	¥175.00	现货
10mg	¥315.00	现货
25mg	¥455.00	现货
50mg	¥595.00	现货
100mg	¥840.00	现货
200mg	¥1,610.00	现货
500mg	¥2,730.00	现货
1g	¥4,095.00	现货
*10mM 1mL in DMSO**	¥210.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Doramapimod (BIRB-796)发表的4篇文献

Vincent de Laat, .et al. , Nat Commun, 2024, Oct 2;15(1):8540 PMID: 39358362

Ken Kobayashi, .et al. , Cell Tissue Res, 2022, Sep;389(3):501-515 PMID: 35748981

Junsuke Uwada, .et al. , Biochem Pharmacol, 2020, Oct 22;182:114297 PMID: 33132165

Perera LMB, .et al. , J Invest Dermatol, 2018, Nov 4. pii: S0022-202X(18)32791-X PMID: 30404019

生物活性

Discription

Doramapimod (BIRB 796) is a small molecule inhibitor of p38 MAPK,which plays a critical role in regulating the production of proinflammatory cytokines.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10148
分子式	C31H37N5O3
分子量	527.7
CAS号	285983-48-4
SMILES	CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	99 mg/mL (187.61 mM)
	Water	Insoluble
	Ethanol	99 mg/mL (187.61 mM)
In vivo	5% DMSO+40%PEG300+5%Tween80??+50%H2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.95 mL	94.75 mL	189.5 mL
0.5 mM	3.79 mL	18.95 mL	37.9 mL
1 mM	1.9 mL	9.48 mL	18.95 mL
5 mM	0.38 mL	1.9 mL	3.79 mL

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