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DUBs-IN-3是一种有效的去泛素酶抑制剂，对USP8的IC50为3.1 uM。选择性是USP7的30倍以上（IC50> 100 uM）。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 34.81 mL | 174.05 mL | 348.09 mL |
| 0.5 mM | 6.96 mL | 34.81 mL | 69.62 mL |
| 1 mM | 3.48 mL | 17.4 mL | 34.81 mL |
| 5 mM | 0.7 mL | 3.48 mL | 6.96 mL |
*The above data is based on the productmolecular weight 287.28. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12830 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 287.28 |
| Formula | C16H9N5O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 924296-17-3 |
| SMILES | C=CCON=C1C2=CC=CC=C2C3=NC(=C(N=C31)C#N)C#N |
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