Signaling Pathway
TLR/SCD 抑制剂
| Discription | E6446 dihydrochloride is a robust antagonist for TLR7 and TLR9, with potential applications in studying harmful inflammatory responses. Additionally, it acts as a significant inhibitor of SCD1 with a KD of 4.61 μM. This compound can notably suppress adipogenic differentiation and liver lipogenesis via the SCD1-ATF3 pathway. Studies have indicated that E6446 dihydrochloride can enhance liver pathology in mice on a high-fat diet, making it a potential candidate for researching non-alcoholic fatty liver disease (NAFLD). |
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| 目录号 | A17149 |
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| 分子式 | C27H37Cl2N3O3 |
| 分子量 | 522.51 |
| CAS号 | 1345675-25-3 |
| SMILES | [H]Cl.[H]Cl.C1(C2=CC=C(OCCCN3CCCC3)C=C2)=NC4=CC=C(OCCCN5CCCC5)C=C4O1 |
| 其他名称 | E 6446, E-6446 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
| In vitro | DMSO | 3 mg/mL (5.74 mM) | |
| Water | 91 mg/mL (174.16 mM) | ||
| Ethanol | 2 mg/mL | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.14 mL | 95.69 mL | 191.38 mL |
| 0.5 mM | 3.83 mL | 19.14 mL | 38.28 mL |
| 1 mM | 1.91 mL | 9.57 mL | 19.14 mL |
| 5 mM | 0.38 mL | 1.91 mL | 3.83 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
