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E7449 is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC50s of 2.0, 1.0, ?50 and ?50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using 32P-NAD+ as substrate.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.51 mL | 157.56 mL | 315.12 mL |
| 0.5 mM | 6.3 mL | 31.51 mL | 63.02 mL |
| 1 mM | 3.15 mL | 15.76 mL | 31.51 mL |
| 5 mM | 0.63 mL | 3.15 mL | 6.3 mL |
*The above data is based on the productmolecular weight 317.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21553 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 317.34 |
| Formula | C18H15N5O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1140964-99-3 |
| Synonyms | E-7449, E 7449 |
| SMILES | O=C1NNC2=C3C1=CC=CC3=NC(CN4CC5=C(C=CC=C5)C4)=N2 |
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