Emavusertib

Name: Emavusertib
SKU: A22489
Price: 175 CNY
Rating: 5 (288 reviews)

目录号: A22489

IRAK4/FLT3 inhibitor

Emavusertib，也被称为 CA-4948，是一种强效的 IRAK4/FLT3 抑制剂，具有抗肿瘤活性。CA-4948 在 ABC DLBCL 和 AML 细胞系中显示出良好的细胞活性。CA-4948 在329种激酶的检测中表现出中到高的选择性，并且展示了理想的 ADME 和 PK 特性，包括在小鼠、大鼠和狗中良好的口服生物利用度，并在相关肿瘤模型中显示出超过90%的肿瘤生长抑制，与体内 PD 调节具有极好的相关性。

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Grouped product items
规格	价格	库存
1mg	¥175.00	现货
2mg	¥245.00	现货
5mg	¥455.00	现货
10mg	¥560.00	现货
25mg	¥1,190.00	现货
50mg	¥2,240.00	现货
100mg	¥3,885.00	现货
*10mM 1mL in DMSO**	¥490.00	现货
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Data Sheet

SDS

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生物活性

Discription

Emavusertib, also known as CA-4948 is a potent IRAK4/FLT3 inhibitor with anti-tumor activity. CA-4948 demonstrated good cellular activity in ABC DLBCL and AML cell lines. CA-4948 demonstrated moderate to high selectivity in a panel of 329 kinases as well as exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with in vivo PD modulation.

产品信息

目录号	A22489
分子式	C24H25N7O5
分子量	491.508
CAS号	1801344-14-8
SMILES	O=C(C1=COC(C2=CC(C)=NC=C2)=N1)NC3=C(N4C[C@H](O)CC4)N=C5C(OC(N6CCOCC6)=N5)=C3
其他名称	CA-4948, CA 4948, CA4948, Emavusertib
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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