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Emavusertib, also known as CA-4948 is a potent IRAK4/FLT3 inhibitor with anti-tumor activity. CA-4948 demonstrated good cellular activity in ABC DLBCL and AML cell lines. CA-4948 demonstrated moderate to high selectivity in a panel of 329 kinases as well as exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with in vivo PD modulation.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.35 mL | 101.73 mL | 203.46 mL |
| 0.5 mM | 4.07 mL | 20.35 mL | 40.69 mL |
| 1 mM | 2.03 mL | 10.17 mL | 20.35 mL |
| 5 mM | 0.41 mL | 2.03 mL | 4.07 mL |
*The above data is based on the productmolecular weight 491.508. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A22489 |
|---|---|
| M. Wt | 491.508 |
| Formula | C24H25N7O5 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 2 years |
| CAS No. | 1801344-14-8 |
| Synonyms | CA-4948, CA 4948, CA4948, Emavusertib |
| SMILES | O=C(C1=COC(C2=CC(C)=NC=C2)=N1)NC3=C(N4C[C@H](O)CC4)N=C5C(OC(N6CCOCC6)=N5)=C3 |
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