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￥ 0.00 Aurora Kinase
| Catalog No. | Inhibitor Name | Aurora A | Aurora B | Aurora C | Other |
|---|---|---|---|---|---|
| A10004 | Alisertib | **** | * | ||
| A10981 | Tozasertib | **** | ** | *** | Bcr-Abl,FLT3 |
| A10109 | Barasertib | * | **** | ||
| A11009 | ZM 447439 | ** | * | LCK,Src,MEK1 | |
| A10601 | MLN8054 | **** | * | LCK,PKA,CK2 | |
| A10715 | Danusertib | *** | ** | ** | Abl,TrkA,RET |
| A10095 | AT9283 | **** | **** | JAK3,JAK2,Abl1 (T315I) | |
| A10494 | JNJ-7706621 | *** | *** | CDK2/CyclinE,CDK2/CyclinA,CDK1/CyclinB | |
| A10448 | Hesperadin | * | TbAUK1 | ||
| A10100 | Aurora A Inhibitor I | **** | * | * | |
| A10508 | KW-2449 | ** | FLT3 (D835Y),Abl (T315I),FLT3 | ||
| A10851 | SNS-314 Mesylate | *** | ** | **** | |
| A10352 | ENMD-2076 | *** | * | FLT3,RET,VEGFR3/FLT4 | |
| A10714 | PHA-680632 | ** | * | * | FGFR1,PLK1,FLT3 |
| A11410 | MK-5108 | **** | |||
| A10248 | CYC116 | *** | *** | VEGFR2,FLT3,CDK2/CyclinE | |
| A11066 | AMG-900 | *** | **** | **** | p38α,TYK2,JNK2 |
| A11171 | PF-03814735 | **** | *** | FLT1,FAK,TrkA | |
| A10184 | CCT129202 | ** | * | * | |
| A11168 | GSK1070916 | * | **** | *** | FLT1,Tie-2,SIK |
| A11067 | TAK-901 | ** | *** | JAK3,c-Src,YES1 | |
| A11081 | CCT137690 | *** | ** | ** | |
| A13396 | MK-8745 | **** | * | ||
| A10352 | ENMD-2076 L-(*)-Tartaric acid | *** | * | FLT3,RET,VEGFR3/FLT4 | |
| A15762 | BI-847325 | ** | **** | *** | |
| A13250 | Reversine | *** | *** | ** | human A3 adenosine receptor |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
37 个项目
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MK-8745
Catalog No. A13396 -
CYC116 (CYC-116)
Catalog No. A10248 Aurora Kinase 抑制剂CYC116 (CYC-116)是一种有效的Aurora A/B抑制剂，Ki为8.0 nM/9.2 nM，对VEGFR2(Ki为44 nM)作用稍弱。 了解更多 -
MK-5108 (VX-689)
Catalog No. A11410 Aurora A Kinase 抑制剂MK-5108，也称为VX-689，是Aurora A激酶ATP结合位点的竞争性抑制剂。 了解更多 -
PHA-680632
Catalog No. A10714 Aurora 抑制剂PHA-680632是Aurora A，Aurora B和Aurora C的有效抑制剂，IC50分别为27 nM，135 nM和120 nM。对于FGFR1，FLT3，LCK，PLK1，STLK2和VEGFR2/3，它的IC50高10到200倍。 了解更多 -
PF-03814735
Catalog No. A11171 Aurora A/B Kinase 抑制剂PF-03814735是一种新颖，有效且可逆的Aurora A/B抑制剂，IC50为0.8 nM/5 nM，对Flt3，FAK，TrkA的效力较低，对Met和FGFR1的活性最低。 了解更多 -
GSK1070916
Catalog No. A11168 Aurora Kinase B/C 抑制剂GSK1070916是一种有效的Aurora B/C激酶抑制剂（IC50为3.5 nM/6.5 nM），在组织培养细胞和人肿瘤异种移植模型中具有广泛的抗肿瘤活性。 了解更多 -
MLN8237 (Alisertib)
Catalog No. A10004 Aurora A Kinase 抑制剂MLN8237 (Alisertib)是一种选择性Aurora A抑制剂，在无细胞分析中的IC50为1.2 nM。它对Aurora A的选择性比Aurora B高200倍以上。 了解更多 -
Hesperadin
Catalog No. A10448 Aurora B Kinase 抑制剂Hesperadin是一种人极光B抑制剂，IC50为40 nM，用于防止底物磷酸化。它显著降低AMPK、Lck、MKK1、MAPKAP-K1、CHK1和PHK的活性，而不抑制MKK1在体内的活性。 了解更多 -
AZD1152-HQPA (Barasertib)
Catalog No. A10109 Aurora Kinase B 抑制剂AZD1152-HQPA (Barasertib)是Aurora B的高效抑制剂，Ki值分别为0.36（Aurora B）和1369 nM（Aurora A），与一组其他50种激酶相比具有很高的特异性。 了解更多 -
VX-680 (MK-0457, Tozasertib)
Catalog No. A10981 Aurora Kinase 抑制剂VX-680 (MK-0457,Tozasertib)是一种有效的选择性Aurora激酶小分子抑制剂。 了解更多 -
Danusertib (PHA-739358)
Catalog No. A10715 Aurora 抑制剂Danusertib (PHA-739358)是Aurora A/B/C的Aurora激酶抑制剂，在无细胞分析中的IC50为13 nM/79nM/61 nM，对Abl，TrkA，c-RET和FGFR1以及更低的浓度具有中等效力 对Lck，VEGFR2/3，c-Kit，CDK2等有效。 了解更多 -
TC-S 7010 (Aurora A Inhibitor I)
Catalog No. A10100 Aurora A 抑制剂TC-S 7010 (Aurora A Inhibitor I)是Aurora A激酶（AurA）的有效和选择性抑制剂，IC50值为3.4 nM（Aurora A），对Aurora B具有极高的选择性1000倍； 用于研究Aurora A激酶的细胞作用的有用工具化合物。 了解更多 -
JNJ-7706621
Catalog No. A10494 CDK/Aurora A/B 抑制剂JNJ-7706621是对CDK1/2具有最高效力的pan-CDK抑制剂，IC50为9 nM/4 nM，并且在无细胞分析中对CDK1/2的选择性是CDK3/4/6的6倍以上。它还能有效抑制极光A/B，对Plk1和Wee1没有活性。 了解更多 -
TC-A-2317 HCl
Catalog No. A13567 Aurora kinase A 抑制剂TC-A-2317 HCl是一种有效的Aurora激酶A抑制剂（Ki = 1.2 nM，而抑制Aurora激酶B则为101 nM）。选择性超过60种其他激酶（IC50值> 1000 nM）。表现出良好的细胞通透性和抗肿瘤活性。 了解更多 -
SCH-1473759
Catalog No. A14059 -
AAPK-25
Catalog No. A19085 Aurora/PLK dual 抑制剂AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. 了解更多 -
SCH-1473759 hydrochloride
Catalog No. A21711 Aurora inhibitorSCH-1473759 hydrochloride is an aurora inhibitor with IC50s of 4 and 13 nM for aurora A and B, respectively. 了解更多 -
Aurora Kinase Inhibitor 3
Catalog No. A19448 Aurora A kinase inhibitorAurora Kinase Inhibitor 3 is a strong and selective Aurora A kinase inhibitor with an IC50 of 42 nM, and weakly inhibits EGFR with an IC50>10 μM. 了解更多 -
Aurora inhibitor 1
Catalog No. A19637 Aurora inhibitorAurora inhibitor 1 is a potent Aurora inhibitor with an IC50 of ?? 4 nM and ??13 nM for Aurora A and Aurora B kinase, respectively. 了解更多
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