HDAC

Inhibitory Selectivity

Catalog No.	Inhibitor Name	HDAC	HDAC1	HDAC2	HDAC3	HDAC4	HDAC5	HDAC6	HDAC7	HDAC8	HDAC9	HDAC10	HDAC11	HD1	HD2
A10979	Vorinostat	****
A10611	Entinostat		**		*
A10518	Panobinostat	****
A10947	Trichostatin A	****
A10586	Mocetinostat		**	**	*								*
A10122	Belinostat	***
A11920	Romidepsin		***	***
A10560	MC1568													*
A11042	Tubastatin A HCl		*					***
A10488	Givinostat													****	****
A10516	Dacinostat	***
A10246	CUDC-101	****	****	***	****	***	***	****	**	**	**	***
A10830	Pracinostat		***	**	***	***	***	*	**	**	**	***	**
A11152	PCI-34051		*					*		****		*
A10337	Droxinostat				*			*		*
A10700	Abexinostat		****	***	****			***		**		***
A13218	RGFP966				**
A11037	AR-42	***
A11940	Ricolinostat		**	***	***	*	*	****	*	**
A11964	Tacedinaline		*	*	*					**
A11153	CUDC-907		****	****	****	**	*	***	**		**	****	****
A11355	M344	**
A10954	Tubacin							****
A13139	RG2833		***		****
A12556	Resminostat		***		***			**
A15489	BRD73954			*				***		**
A11361	BG45		*	*	**
A14354	4SC-202		*	*	*
A16431	CAY10603		**					****
A14341	LMK-235					***	****
A14032	Nexturastat A							****
A14128	TMP269					**	**		***		***
A14197	HPOB		*	*	*			***		*		*
A12722	Scriptaid
A12616	Tasquinimod
A11042	Tubastatin A							***

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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MGCD0103 (Mocetinostat)

Catalog No. A10586
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HDAC 抑制剂

MGCD0103 (Mocetinostat)是一种苯甲酰胺组蛋白脱乙酰基酶抑制剂，主要抑制组蛋白脱乙酰基酶1（HDAC1），但也抑制HDAC2，HDAC3和HDAC11。了解更多

Product Citations (2)

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- Mari Ishigami-Yuasa, .et al. Class IIb HDAC Inhibition Enhances the Inhibitory Effect of Am80, a Synthetic Retinoid, in Prostate Cancer, Biol Pharm Bull, 2019, 42, 448-452
- Guang Bai, .et al. Chapter 1 - Epigenetic Tools in Chronic Pain Studies, Epigenetics of Chronic Pain, 2019, Pages 1-48
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Romidepsin (FK228 ,Depsipeptide)

Catalog No. A11920
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HDAC 抑制剂

Romidepsin (FK228,Depsipeptide)抑制HDAC1和HDAC2，IC50分别为1.6 nM和3.9 nM，但相对较弱地分别抑制HDAC4和HDAC6，IC50值为25 nM和79 nM。了解更多

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- Yu-Fang Liu, .et al. Effects of dexmedetomidine on cognitive dysfunction andneuroinflammation via the HDAC2/HIF?\1α/PFKFB3 axis in amurine model of postoperative cognitive dysfunction, J Biochem Mol Toxicol, 2022, Jun;36(6):e23044 PMID: 35499365
- David Diaz-Carballo, .et al. Enhanced antitumoral activity of TLR7 agonists via activation of human endogenous retroviruses by HDAC inhibitors, Commun Biol, 2021, Mar 3;4(1):276 PMID: 33658617
- Eva Hesping, .et al. An ELISA method to assess HDAC inhibitor-induced alterations to P. falciparum histone lysine acetylation, Int J Parasitol Drugs Drug Resist, 2020, 14: 249-256
- Shariful Islam, .et al. Resistance to histone deacetylase inhibitors confers hypersensitivity to oncolytic reovirus therapy, Blood Adv, 2020, 4(20): 5297-5310 PMID: 33108458
- Elena Netchiporouk, .et al. Analysis of CTCL cell lines reveals important differences between mycosis fungoides/Sézary syndrome vs. HTLV-1+ leukemic cell lines, Oncotarget, 2017, Nov 10; 8(56): 95981-95998 PMID: 29221181
- Ivan V. Litvinov, .et al. Ectopic expression of cancer testis antigens in Cutaneous T-Cell Lymphoma (CTCL) patients, Clin Cancer Res, 2014, 20(14): 3799-3808 PMID: 24850846
- Ivan V Litvinov, .et al. Analysis of STAT4 expression in cutaneous T-cell lymphoma (CTCL) patients and patient-derived cell lines, Cell Cycle., 2014, 15; 13(18): 2975-2982 PMID: 25486484
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CUDC-907 (Fimepinostat)

Catalog No. A11153
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PI3K/HDAC 抑制剂

CUDC-907 (Fimepinostat)是针对PI3K和HDAC的单一小分子抑制剂，作用于PI3Kα和HDAC1/2/3/10，IC50分别为19 nM和1.7 nM/5 nM/1.8 nM/2.8 nM。了解更多

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- Chie Ishikawa, .et al. The role of CUDC-907, a dual phosphoinositide-3 kinase and histone deacetylase inhibitor, in inhibiting proliferation of adult T-cell leukemia, Eur J Haematol, 2020, Eur J Haematol PMID: 32780889
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KD 5170

Catalog No. A15354
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HDAC 抑制剂

KD 5170是一种新型的基于巯基酮的组蛋白脱乙酰基酶抑制剂，在体外和体内均表现出广谱的抗肿瘤活性。了解更多

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HDAC-IN-7

Catalog No. A21252
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HDAC1/2/3/10 inhibitor

HDAC-IN-7 (Chidamide impurity) is an impurity of Chidamide. Chidamide is a potent and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor. 了解更多

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CI994 (Tacedinaline)

Catalog No. A11964
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HDAC 抑制剂

CI994 (Tacedinaline)是一种组蛋白脱乙酰基酶（HDAC）抑制剂，可在活细胞中诱导组蛋白超乙酰化。了解更多

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Valproic acid

Catalog No. A17323
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HDAC inhibitor

Valproic acid is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2; Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches. 了解更多

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- Dan Zhao, .et al. From crypts to enteroids: establishment and characterization of avian intestinal organoids, Poult Sci, 2022, Mar; 101(3): 101642 PMID: 35016046
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Domatinostat (4SC-202)

Catalog No. A14354
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HDAC 抑制剂

4SC-202是生物利用的苯甲酰胺和人I类组蛋白脱乙酰基酶（HDACs）同工酶1、2和3的抑制剂，具有潜在的抗肿瘤活性。了解更多

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SR-4370

Catalog No. A16899
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HDAC 抑制剂

SR-4370是HDAC抑制剂。SR-4370对HDAC1，HDAC2和HDAC3的IC50值分别为0.5 uM，0.1 uM和0.06 uM。了解更多

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UF010

Catalog No. A15781
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HADC 抑制剂

UF010是一种有效的选择性HADC抑制剂，对于HDAC 3、2、1和8分别具有IC50?0.06 uM，0.1 uM，0.5 uM和1.5 uM。它的选择性是其他HDAC的6倍以上。了解更多

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BRD-6929

Catalog No. A12511
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HDAC1/HDAC2 inhibitor

BRD-6929 (Cpd-60) is a brain-penetrant, selective inhibitor of HDAC1 and HDAC2 (IC50=?1 and 8 nM), extracted from patent US2018360927. 了解更多

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Tinostamustine (EDO-S101)

Catalog No. A18342
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HDAC inhibitor

EDO-S101 is a pan HDAC inhibitor; inhibits HDAC1, HDAC2 and HDAC3 with IC50 values of 9, 9 and 25 nM, respectively. 了解更多

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Santacruzamate A

Catalog No. A14236
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HDAC 抑制剂

Santacruzamate A (CAY10683)是一种有效的选择性HDAC抑制剂，对HDAC2的IC50为119 pM，选择性是其他HDAC的3600倍以上。了解更多

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BG45

Catalog No. A11361
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HDAC 抑制剂

BG45是一种HDAC I类抑制剂，对HDAC3具有选择性（IC50 = 289 nM）。它抑制HDAC1，HDAC2和HDAC6的效力大大降低（IC50分别为2、2和> 20μM）。了解更多

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TC-H 106

Catalog No. A15357
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HDAC 抑制剂

TC-H 106是一种慢速，紧密结合的I类HDAC（组蛋白脱乙酰基酶）抑制剂。了解更多

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