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Epothilone A 通过稳定紫杉醇结合位点处的微管形成而起作用，并导致细胞周期停滞在G2/M转变，从而导致细胞毒性。
靶点信息
| Tubulin | ||||
| 2 μM(EC0.01) |
| In vitro | DMSO | 92 mg/mL (186.36 mM) | |
| Water | Insoluble | ||
| Ethanol | 92 mg/mL (186.36 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.26 mL | 101.28 mL | 202.55 mL |
| 0.5 mM | 4.05 mL | 20.26 mL | 40.51 mL |
| 1 mM | 2.03 mL | 10.13 mL | 20.26 mL |
| 5 mM | 0.41 mL | 2.03 mL | 4.05 mL |
*The above data is based on the productmolecular weight 493.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10359 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 493.7 |
| Formula | C26H39NO6S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 152044-53-6 |
| Synonyms | EpoA, Epothilone-A |
| SMILES | C[C@H]1CCC[C@@H]2[C@@H](O2)C[C@H](OC(=O)C[C@@H](C(C(=O)[C@@H]([C@H]1O)C)(C)C)O)/C(=C/C3=CSC(=N3)C)/C |
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