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EPZ-5676 (Pinometostat)

目录号: A12735

DOT1L 抑制剂?

EPZ-5676 (Pinometostat)

EPZ-5676 (Pinometostat) Chemical Structure

CAS NO. 1380288-87-8

EPZ-5676 (Pinometostat)是组蛋白甲基转移酶的小分子抑制剂，具有潜在的抗肿瘤活性。

库存： 现货

规格 价格 数量
5 mg
￥ 455.00
10 mg
￥ 630.00
25 mg
￥ 1,155.00
50 mg
￥ 2,275.00
10mM * 1mL in DMSO
￥ 1,043.00
或
Warning 产品仅用于科学研究，不针对患者销售，望谅解.
产品详情

生物活性

EPZ-5676 (Pinometostat)是组蛋白甲基转移酶的小分子抑制剂，具有潜在的抗肿瘤活性。
靶点信息
DOT1L (Cell-free assay)
80 pM(Ki)

溶解度 *

In vitro (25°C) DMSO Warmed: 88 mg/mL (156.38 mM)
Water Insoluble
Ethanol Warmed: 81 mg/mL (143.94 mM)
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.77 mL 88.86 mL 177.71 mL
0.5 mM 3.55 mL 17.77 mL 35.54 mL
1 mM 1.78 mL 8.89 mL 17.77 mL
5 mM 0.36 mL 1.78 mL 3.55 mL

*The above data is based on the productmolecular weight 562.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号 A12735
作用机制 Inhibitor (抑制剂)
M. Wt 562.7
Formula C30H42N8O3
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No. 1380288-87-8
Synonyms EPZ5676, EPZ 5676
SMILES CC(C)N(C[C@@H]1[C@H]([C@H]([C@@H](O1)N2C=NC3=C2N=CN=C3N)O)O)C4CC(C4)CCC5=NC6=C(N5)C=C(C=C6)C(C)(C)C

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