产品详情

生物活性

EPZ004777是dot1l的有效选择性抑制剂。epz004777选择性抑制细胞h3k79甲基化并抑制关键mll融合靶基因的表达。

靶点信息

DOT1L (Cell-free assay)
0.4 nM

溶解度 *

In vitro	DMSO	95 mg/mL (176.03 mM)
	Water	Insoluble
	Ethanol	95 mg/mL (176.03 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.53 mL	92.65 mL	185.3 mL
0.5 mM	3.71 mL	18.53 mL	37.06 mL
1 mM	1.85 mL	9.26 mL	18.53 mL
5 mM	0.37 mL	1.85 mL	3.71 mL

*The above data is based on the productmolecular weight 539.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12983
作用机制	Inhibitor (抑制剂)
M. Wt	539.67
Formula	C28H41N7O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1338466-77-5
Synonyms	EPZ 004777, EPZ-004777
SMILES	CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC4=C3N=CN=C4N)O)O