EPZ004777

Name: EPZ004777
SKU: A12983
Price: 175 CNY
Rating: 5 (288 reviews)

目录号: A12983

DOT1L 抑制剂

EPZ004777 是一种强效的、选择性的 DOT1L 抑制剂。EPZ004777 选择性地抑制细胞内的 H3K79 甲基化，并抑制关键的 MLL 融合靶基因的表达。

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Grouped product items
规格	价格	库存
1mg	¥175.00	现货
5mg	¥455.00	现货
10mg	¥735.00	现货
25mg	¥1,505.00	现货
50mg	¥2,485.00	现货
100mg	¥3,850.00	现货
*10mM 1mL in DMSO**	¥560.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

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生物活性

Discription

EPZ004777 is a potent, selective inhibitor of DOT1L. EPZ004777 selectively inhibits cellular H3K79 methylation and inhibits expression of key MLL fusion target genes.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A12983
分子式	C28H41N7O4
分子量	539.67
CAS号	1338466-77-5
SMILES	CC(C)N(CCCNC(=O)NC1=CC=C(C=C1)C(C)(C)C)C[C@@H]2[C@H]([C@H]([C@@H](O2)N3C=CC4=C3N=CN=C4N)O)O
其他名称	EPZ 004777, EPZ-004777
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	95 mg/mL (176.03 mM)
	Water	Insoluble
	Ethanol	95 mg/mL (176.03 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.53 mL	92.65 mL	185.3 mL
0.5 mM	3.71 mL	18.53 mL	37.06 mL
1 mM	1.85 mL	9.26 mL	18.53 mL
5 mM	0.37 mL	1.85 mL	3.71 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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