EPZ011989
目录号: A15544
EZH2 抑制剂
EPZ011989 是一种高效、选择性的口服生物利用度 EZH2 抑制剂,对 EZH2 wt 和 EZH2 Y646 的 Ki 值小于 3 nM;对 EZH1 的选择性高出 15 倍,对其他 HMTase 的选择性高出 3000 倍以上。
Discription | EPZ011989 is a potent, selective orally bioavailable EZH2 inhibitor with Ki < 3 nM for EZH2 wt and EZH2 Y646; 15-fold selectivity over EZH1 and >3000-fold selectivity over other HMTase. |
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目录号 | A15544 |
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分子式 | C35H51N5O4 |
分子量 | 605.81 |
CAS号 | 1598383-40-4 |
SMILES | CCN(C1CCC(CC1)N(C)CCOC)C2=CC(=CC(=C2C)C(=O)NCC3=C(C=C(NC3=O)C)C)C#CCN4CCOCC4 |
其他名称 | EPZ-011989, EPZ 011989 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2