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Erlotinib hydrochloride是一种可逆的酪氨酸激酶抑制剂，作用于表皮生长因子受体（EGFR）。
靶点信息
| HER1/EGFR (Cell-free assay) | ||||
| 2 nM |
| In vitro (25°C) | DMSO | Warmed: 4 mg/mL (9.3 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 15% Captisol | 15 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.26 mL | 116.31 mL | 232.61 mL |
| 0.5 mM | 4.65 mL | 23.26 mL | 46.52 mL |
| 1 mM | 2.33 mL | 11.63 mL | 23.26 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.65 mL |
*The above data is based on the productmolecular weight 429.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10362 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 429.9 |
| Formula | C22H23N3O4.HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 183319-69-9 |
| Synonyms | CP-358774, OSI-774, NSC 718781 |
| SMILES | COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC.Cl |
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