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Etoposide (VP-16)是通过抑制topoisomerase II活性而抑制DNA合成。
靶点信息
| Topo II (Cell-free assay) | ||||
| In vitro (25°C) | DMSO | 99 mg/mL (168.2 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+40% PEG 300+5% Tween 80+ddH2O | 14 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.99 mL | 84.95 mL | 169.89 mL |
| 0.5 mM | 3.4 mL | 16.99 mL | 33.98 mL |
| 1 mM | 1.7 mL | 8.49 mL | 16.99 mL |
| 5 mM | 0.34 mL | 1.7 mL | 3.4 mL |
*The above data is based on the productmolecular weight 588.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10373 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 588.6 |
| Formula | C29H32O13 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 33419-42-0 |
| Synonyms | VP16, Vepesid, etoposide phosphate |
| SMILES | C[C@@H]1OC[C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O |
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