Etoposide (VP-16)

Name: Etoposide (VP-16)
SKU: A10373
Price: 175 CNY
Rating: 5 (10 reviews)

目录号: A10373

Topoisomerase II 抑制剂

10 篇发表文献

依托泊苷与DNA和拓扑异构酶II（帮助DNA解旋）形成三元复合物，阻止DNA链的重新连接，并因此导致DNA链断裂。因此，这会导致DNA合成出错，并促进癌细胞的凋亡。

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规格	价格	库存
50mg	¥175.00	现货
100mg	¥280.00	现货
200mg	¥525.00	现货
500mg	¥700.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Etoposide (VP-16)发表的10篇文献

Bageshri Naimish Nanavati, .et al. , Curr Biol, 2024, Sep 9;34(17):4081-4090 PMID: 39153481

Wan J Gan, .et al. , Cytoskeleton (Hoboken), 2024, Jul 10 PMID: 38984538

Wan J. Gan, .et al. , bioRxiv, 2024, March 10

Zoya Mann, .et al. , Mol Biol Cell, 2024, Jan 1; 35(1) PMID: 37903230

Bageshri Naimish Nanavati, .et al. , bioRxiv, 2023, Feb 23 PMID: 36865131

Sibei Wang, .et al. , Molecules, 2023, Jan 19;28(3):1016 PMID: 36770683

Reiko Watanabe, .et al. , J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967

Chen JC, .et al. , Biomolecules, 2019, Sep 9;9(9) PMID: 31505885

Takashi Azuma, .et al. , SEP PURIF TECHNOL, 2019, Apr; 212: 483-489

Calhelha RC, .et al. , Analyst, 2017, Oct 23;142(21):4124-4141 PMID: 28991301

生物活性

Discription

Etoposide forms a ternary complex with DNA and the topoisomerase II enzyme (which aids in DNA unwinding), prevents re-ligation of the DNA strands, and by doing so causes DNA strands to break. Therefore, this causes errors in DNA synthesis and promotes apoptosis of the cancer cell.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10373
分子式	C29H32O13
分子量	588.6
CAS号	33419-42-0
SMILES	C[C@@H]1OC[C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O
其他名称	Vepesid
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	99 mg/mL (168.2 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+40% PEG 300+5% Tween 80+ddH2O	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.99 mL	84.95 mL	169.89 mL
0.5 mM	3.4 mL	16.99 mL	33.98 mL
1 mM	1.7 mL	8.49 mL	16.99 mL
5 mM	0.34 mL	1.7 mL	3.4 mL

Useful Calculator

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Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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