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Exatecan mesylate可通过稳定拓扑异构酶I与DNA之间的可裂解复合物并抑制DNA断裂的连接来抑制拓扑异构酶I的活性，从而抑制DNA复制并触发凋亡性细胞死亡。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.96 mL | 114.82 mL | 229.64 mL |
| 0.5 mM | 4.59 mL | 22.96 mL | 45.93 mL |
| 1 mM | 2.3 mL | 11.48 mL | 22.96 mL |
| 5 mM | 0.46 mL | 2.3 mL | 4.59 mL |
*The above data is based on the productmolecular weight 435.4554. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11231 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 435.4554 |
| Formula | C24H22FN3O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 171335-80-1 |
| Synonyms | DX 8951, DX8951 |
| SMILES | CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C5[C@H](CCC6=C5C(=CC(=C6C)F)N=C4C3=C2)N)O |
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