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Exemestane是一种口服类固醇芳香化酶抑制剂，除绝经后妇女的手术和/或放疗外，还用于ER阳性乳腺癌。
靶点信息
| Aromatase (human) | Aromatase (rat) | |||
| 30 nM | 40 nM |
| In vitro | DMSO | 52 mg/mL (175.43 mM) | |
| Water | Insoluble | ||
| Ethanol | 15 mg/mL (50.6 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 33.74 mL | 168.69 mL | 337.38 mL |
| 0.5 mM | 6.75 mL | 33.74 mL | 67.48 mL |
| 1 mM | 3.37 mL | 16.87 mL | 33.74 mL |
| 5 mM | 0.67 mL | 3.37 mL | 6.75 mL |
*The above data is based on the productmolecular weight 296.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10378 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 296.4 |
| Formula | C20H24O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 107868-30-4 |
| Synonyms | Aromasin |
| SMILES | C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CC(=C)C4=CC(=O)C=C[C@]34C |
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