Ezetimibe (Zetia)
目录号: A10379
Ezetimibe 是一种降低胆固醇的化合物。它通过减少肠道中的胆固醇吸收来起作用。Ezetimibe 定位于小肠的刷状缘,在那里抑制肠道中的胆固醇吸收。
Discription | Ezetimibe is a compound that lowers cholesterol. It acts by decreasing cholesterol absorption in the intestine. Ezetimibe localises at the brush border of the small intestine, where ezetimibe inhibits the absorption of cholesterol from the intestine. |
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目录号 | A10379 |
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分子式 | C24H21F2NO3 |
分子量 | 409.4 |
CAS号 | 163222-33-1 |
SMILES | C1=CC(=CC=C1[C@@H]2[C@H](C(=O)N2C3=CC=C(C=C3)F)CC[C@@H](C4=CC=C(C=C4)F)O)O |
其他名称 | Zetia , Ezetrol |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
In vitro (25°C) | DMSO | 75 mg/mL (183.19 mM) | |
Water | Insoluble | ||
Ethanol | 75 mg/mL (183.19 mM) | ||
In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 9 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 24.43 mL | 122.13 mL | 244.26 mL |
0.5 mM | 4.89 mL | 24.43 mL | 48.85 mL |
1 mM | 2.44 mL | 12.21 mL | 24.43 mL |
5 mM | 0.49 mL | 2.44 mL | 4.89 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2