Factor Xa

Inhibitory Selectivity

Catalog No.	Inhibitor Name	Factor Xa	Other
A10800	Rivaroxaban	**	Prothrombinase
A10082	Apixaban	****
A14317	Edoxaban	***	Thrombin,FIXa

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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Edoxaban tosylate

Catalog No. A15076
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Factor Xa 抑制剂

Edoxaban tosylate是临床预防卒中的口服Xa（FXa）抑制剂。了解更多

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5-R-Rivaroxaban

Catalog No. A14979
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Factor Xa 抑制剂

5-R-Rivaroxaban是利伐沙班的（R）对映异构体。利伐沙班是一种新型的口服直接Xa因子抑制剂，在晚期开发中用于预防和治疗血栓栓塞性疾病。了解更多

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Edoxaban (tosylate Monohydrate)

Catalog No. A14317
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Factor Xa 抑制剂

Edoxaban (tosylate Monohydrate)是选择性Factor Xa抑制剂，Ki为0.561 nM。了解更多

Product Citations (1)

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- Daniël Verhoef, .et al. Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors, Nat Commun, 2017, 8: 528 PMID: 28904343
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DPC-423

Catalog No. A14099
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factor Xa 抑制剂

DPC423是一种高效且可口服生物利用的吡唑抗血栓形成剂。了解更多

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ABT333

Catalog No. A13878
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NS5B 抑制剂

ABT333是NS5B非核苷聚合酶抑制剂。了解更多

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Betrixaban

Catalog No. A12518
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FXa 抑制剂

Betrixaban是一种抗凝血药，可作为直接Xa因子抑制剂。它具有强大的，口服活性和对因子Xa的高度选择性，由于其低hERG亲和力而从一组相似的化合物中选择。了解更多

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Rivaroxaban Diol

Catalog No. A12411
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Rivaroxaban Diol是恶唑烷酮衍生物，经优化可抑制凝血酶原酶复合物中结合的游离因子Xa和因子Xa。了解更多

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Letaxaban (TAK-442)

Catalog No. A12871
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factor Xa 抑制剂

Letaxaban (TAK-442)是一种有效的，选择性的，口服活性的Xa抑制剂，是一种四氢嘧啶-2（1H）-衍生物。TAK-442在贫血小板的人[半最大抑制浓度（IC（50））：53 nM，TAK-442]和大鼠（IC（50）：32 nM，TAK-442）血浆中抑制内源性FXa活性。了解更多

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Razaxaban

Catalog No. A12870
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factor Xa 抑制剂

Razaxaban是凝血因子Xa的选择性，有效和口服生物利用抑制剂。了解更多

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Otamixaban (FXV 673)

Catalog No. A11517
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factor Xa 抑制剂

Otamixaban (FXV 673)是一种静脉内直接因子Xa抑制剂。了解更多

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- Tim Hempel, .et al. Synergistic inhibition of SARS-CoV-2 cell entry by otamixaban and covalent protease inhibitors: preclinical assessment of pharmacological and molecular properties, Chemical Science, 2021, 12, 12600-12609
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Rivaroxaban (Xarelto)

Catalog No. A10800
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Factor Xa 抑制剂

Rivaroxaban (Xarelto)是一种Factor Xa的直接抑制剂，无细胞试验中Ki和IC50分别为0.4 nM和0.7 nM。了解更多

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- Stefan Bittmann, .et al. TMPRSS2-Inhibitors Play a role in Cell Entry Mechanism of COVID-19: An Insight into Camostat and Nafamostat, J Regen Biol Med, 2020, 2(2):1-3
- Daniël Verhoef, .et al. Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors, Nat Commun, 2017, 8: 528 PMID: 28904343
- Mizuki Yamamoto, .et al. Identification of Nafamostat as a Potent Inhibitor of Middle East Respiratory Syndrome Coronavirus S Protein-Mediated Membrane Fusion Using the Split-Protein-Based Cell-Cell Fusion Assay, Antimicrob Agents Chemother, 2016, Nov; 60(11): 6532-6539 PMID: 27550352
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BMS-740808

Catalog No. A10158
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Factor Xa 抑制剂

BMS-740808是凝血因子Xa的高效，选择性，有效和口服生物利用度抑制剂。了解更多

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Apixaban (BMS-562247-01)

Catalog No. A10082
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Factor Xa 抑制剂

Apixaban (BMS-562247-01)是一种抗凝剂，用于预防静脉血栓栓塞和静脉血栓栓塞事件。了解更多

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- Daniël Verhoef, .et al. Engineered factor Xa variants retain procoagulant activity independent of direct factor Xa inhibitors, Nat Commun, 2017, 8: 528 PMID: 28904343
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Fondaparinux Sodium

Catalog No. A17918
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factor Xa inhibitor

Fondaparinux sodium is a factor Xa inhibitor to form the high affinity binding site for the anti-coagulant factor antithrombin III (ATIII). 了解更多

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RWJ-445167

Catalog No. A12154
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dual inhibitor of thrombin and factor Xa

RWJ-445167 (3DP-10017) is a dual inhibitor of thrombin and factor Xa with Ki of 4.0 nM and 230 nM, respectively, exhibiting potent antithrombotic activity. 了解更多

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Edoxaban

Catalog No. A18015
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factor Xa (FXa) inhibitor

Edoxaban(DU-176) is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention. 了解更多

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BMS-654457

Catalog No. A21704
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Factor XIa (FXIa) inhibitor

BMS-654457 is a small-molecule, reversible inhibitor of factor XIa (FXIa), binding with human and rabbit FXIa with Kis of 0.2 and 0.42 nM, respectively. 了解更多

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