FIPI
目录号: A13895
PLD inhibitor
磷脂酶D（PLD）的同工异构体可以切断磷脂的头基团，释放第二信使磷脂酸（PA），这可能导致Ras激活、细胞扩散、应力纤维形成、趋化性以及膜囊泡运输的变化。FIPI是halopemide的衍生物，能强效抑制PLD1（IC50 = 25 nM）和PLD2（IC50 = 20 nM）。
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生物活性
| Discription | Isoforms of phospholipase D (PLD) cleave the head group from phospholipids, releasing the second messenger phosphatidic acid (PA), which can produce changes in Ras activation, cell spreading, stress fiber formation, chemotaxis, and membrane vesicle trafficking. FIPI is a derivative of halopemide which potently inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC50 = 20 nM). |
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| Cell Research |
产品信息
| 目录号 | A13895 |
|---|---|
| 分子式 | C23H24FN5O2 |
| 分子量 | 421.5 |
| CAS号 | 939055-18-2 |
| SMILES | C1CN(CCC1N2C3=CC=CC=C3NC2=O)CCNC(=O)C4=CC5=C(N4)C=CC(=C5)F |
| 其他名称 | 5-Fluoro-2-Indolyl des-Chlorohalopemide |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 40 mg/mL (94.9 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.72 mL | 118.62 mL | 237.25 mL |
| 0.5 mM | 4.74 mL | 23.72 mL | 47.45 mL |
| 1 mM | 2.37 mL | 11.86 mL | 23.72 mL |
| 5 mM | 0.47 mL | 2.37 mL | 4.74 mL |
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