FK-506 (Tacrolimus)

Name: FK-506 (Tacrolimus)
SKU: A10389
Price: 175 CNY
Rating: 5 (2 reviews)

目录号: A10389

mTOR 抑制剂

2 篇发表文献

FK-506 是一种免疫抑制药物，主要用于异体器官移植后，通过降低患者免疫系统的活性，从而减少器官排斥的风险。它通过减少 T 细胞产生的白细胞介素-2 (IL-2) 来发挥作用。

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Grouped product items
规格	价格	库存
5mg	¥175.00	现货
10mg	¥210.00	现货
25mg	¥350.00	现货
50mg	¥350.00	现货
100mg	¥665.00	现货
200mg	¥1,015.00	现货
500mg	¥1,715.00	现货
*10mM 1mL in DMSO**	¥280.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用FK-506 (Tacrolimus)发表的2篇文献

Ogawa Y, .et al. , Neurobiol Dis, 2018, Oct;118:142-154 PMID: 30026035

Yuko Okamoto, .et al. , J Drug Deliv Sci Technol, 2018, 47: 62-66

生物活性

Discription

FK-506 is an immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system and so lower the risk of organ rejection. It reduces interleukin-2 (IL-2) production by T-cells.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10389
分子式	C44H69NO12
分子量	804
CAS号	104987-11-3
SMILES	C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC
其他名称	Fujimycin, Prograf , Tacrolimus
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	81 mg/mL (100.74 mM)
	Water	Insoluble
	Ethanol	71 mg/mL (88.31 mM)
In vivo	5% DMSO+corn oil	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	12.44 mL	62.19 mL	124.38 mL
0.5 mM	2.49 mL	12.44 mL	24.88 mL
1 mM	1.24 mL	6.22 mL	12.44 mL
5 mM	0.25 mL	1.24 mL	2.49 mL

Useful Calculator

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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