FK-506 (Tacrolimus)

Name: FK-506 (Tacrolimus)
SKU: A10389

目录号: A10389

mTOR 抑制剂

Product Citations (2)

FK-506 (Tacrolimus) Chemical Structure

CAS NO. 104987-11-3

FK-506 (Tacrolimus)是一种免疫抑制药物，通过结合到抑免蛋白FKBP12 (FK506 结合蛋白)产生新的复合物，从而降低T细胞中肽酰脯氨酰异构酶活性。

库存：现货

规格	价格	数量
50 mg	￥ 385.00
100 mg	￥ 700.00
500 mg	￥ 1,750.00
10mM * 1mL in DMSO	￥ 476.00

或

添加到收藏

产品仅用于科学研究，不针对患者销售，望谅解.

产品详情

生物活性

FK-506 (Tacrolimus)是一种免疫抑制药物，通过结合到抑免蛋白FKBP12 (FK506 结合蛋白)产生新的复合物，从而降低T细胞中肽酰脯氨酰异构酶活性。

靶点信息

FKBP12 (T cells)

溶解度 *

In vitro (25°C)	DMSO	81 mg/mL (100.74 mM)
	Water	Insoluble
	Ethanol	71 mg/mL (88.31 mM)
In vivo	5% DMSO+corn oil	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	12.44 mL	62.19 mL	124.38 mL
0.5 mM	2.49 mL	12.44 mL	24.88 mL
1 mM	1.24 mL	6.22 mL	12.44 mL
5 mM	0.25 mL	1.24 mL	2.49 mL

*The above data is based on the productmolecular weight 804. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10389
作用机制	Inhibitor (抑制剂)
M. Wt	804
Formula	C44H69NO12
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	104987-11-3
Synonyms	FK506, Fujimycin, Prograf , Tacrolimus
SMILES	C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)\C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC