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Fludarabine或fludarabine(fludara)是一种用于治疗血液恶性肿瘤(血细胞癌，如白血病和淋巴瘤)的化疗药物。Fludarabine通过干扰核糖核苷酸还原酶和DNA聚合酶来抑制DNA合成。它对分裂细胞和静止细胞都有活性。
靶点信息
| STAT1 (Vascular smooth muscle cells) | ||||
| In vitro (25°C) | DMSO | 52 mg/mL (182.3 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 30% propylene glycol, 5% Tween 80, 65% D5W | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 35.06 mL | 175.32 mL | 350.63 mL |
| 0.5 mM | 7.01 mL | 35.06 mL | 70.13 mL |
| 1 mM | 3.51 mL | 17.53 mL | 35.06 mL |
| 5 mM | 0.7 mL | 3.51 mL | 7.01 mL |
*The above data is based on the productmolecular weight 285.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10396 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 285.2 |
| Formula | C10H12FN5O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 21679-14-1 |
| Synonyms | F-ara-A, NSC 118218 |
| SMILES | OC[C@@H]1O[C@@H]([C@@H]([C@H]1O)O)[C@@H]1C=Nc2c1nc(F)nc2N |
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