FM-381

Name: FM-381
SKU: A16805
Price: 280 CNY
Rating: 5 (288 reviews)

目录号: A16805

JAK3 抑制剂

FM-381 是一种针对 JAK3 的特异性可逆共价抑制剂，其对 JAK3 的 IC50 为 127 pM，并分别对 JAK1、JAK2 和 TYK2 表现出 400 倍、2,700 倍和 3,600 倍的选择性。

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Grouped product items
规格	价格	库存
1mg	¥280.00	现货
2mg	¥525.00	现货
5mg	¥735.00	现货
10mg	¥1,085.00	现货
25mg	¥2,310.00	现货
50mg	¥3,395.00	现货
100mg	¥5,005.00	现货
*10mM 1mL in DMSO**	¥840.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

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生物活性

Discription	FM-381 is a JAK3 specific reversible covalent inhibitor with IC50 of 127 pM for JAK3 and demonstrates 400-, 2,700- and 3,600-fold selectivity over JAK1, JAK2, and TYK2, respectively.

产品信息

目录号	A16805
分子式	C24H24N6O2
分子量	428.496
CAS号	2226521-65-7
SMILES	O=C(N(C)C)/C(C#N)=C/C(O1)=CC=C1C2=NC3=CN=C(NC=C4)C4=C3N2C5CCCCC5
其他名称	FM 381, FM381
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	20 mg/mL (46.67 mM)
	Water	Insoluble
	Ethanol	2 mg/mL (4.66 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.34 mL	116.69 mL	233.37 mL
0.5 mM	4.67 mL	23.34 mL	46.67 mL
1 mM	2.33 mL	11.67 mL	23.34 mL
5 mM	0.47 mL	2.33 mL	4.67 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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