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Foretinib (GSK1363089, XL880)

Foretinib (GSK1363089, XL880)

Name: Foretinib (GSK1363089, XL880)
SKU: A10998

目录号: A10998

c-MET 抑制剂

Product Citations (4)

Foretinib (GSK1363089, XL880) Chemical Structure

CAS NO. 849217-64-7

Foretinib (GSK1363089,XL880)是c-Met和VEGFR-2的多激酶抑制剂，可抑制增殖，诱导Anoikis并损害卵巢癌转移。

库存：现货

规格	价格	数量
5 mg	￥ 280.00
25 mg	￥ 840.00
50 mg	￥ 1,540.00
100 mg	￥ 2,520.00
10mM * 1mL in DMSO	￥ 490.00

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生物活性

Foretinib (GSK1363089,XL880)是c-Met和VEGFR-2的多激酶抑制剂，可抑制增殖，诱导Anoikis并损害卵巢癌转移。

Targets

Target	Value
Met	IC50: 0.4nM
KDR	IC50: 0.86nM
Tie-2	IC50: 1.1nM
VEGFR3/FLT4	IC50: 2.8nM
RON	IC50: 3nM
FLT3	IC50: 3.6nM
PDGFRα	IC50: 3.6nM
Kit	IC50: 6.7nM
VEGFR1/FLT1	IC50: 6.8nM
PDGFRβ	IC50: 9.6nM
FGFR1	IC50: 660nM
EGFR	IC50: 2.99μM

溶解度 *

In vitro (25°C)	DMSO	87 mg/mL (137.51 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.81 mL	79.03 mL	158.05 mL
0.5 mM	3.16 mL	15.81 mL	31.61 mL
1 mM	1.58 mL	7.9 mL	15.81 mL
5 mM	0.32 mL	1.58 mL	3.16 mL

*The above data is based on the productmolecular weight 632.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10998
作用机制	Inhibitor (抑制剂)
M. Wt	632.7
Formula	C34H34F2N4O6
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	849217-64-7
Synonyms	GSK089, EXEL-2880
SMILES	COC1=CC2=C(C=CN=C2C=C1OCCCN3CCOCC3)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F