Foretinib (GSK1363089, XL880)

Name: Foretinib (GSK1363089, XL880)
SKU: A10998
Price: 175 CNY
Rating: 5 (6 reviews)

目录号: A10998

c-MET 抑制剂

6 篇发表文献

Foretinib（GSK1363089），一种针对 c-Met 和 VEGFR-2 的多激酶抑制剂，能够阻断增殖，诱导无基质细胞凋亡（Anoikis），并且阻碍卵巢癌的转移。

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Grouped product items
规格	价格	库存
2mg	¥175.00	现货
5mg	¥245.00	现货
10mg	¥455.00	现货
25mg	¥805.00	现货
50mg	¥1,470.00	现货
100mg	¥2,485.00	现货
500mg	¥6,195.00	现货
*10mM 1mL in DMSO**	¥455.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Foretinib (GSK1363089, XL880)发表的6篇文献

Ayaka Kojima, .et al. , Xenobiotica, 2022, Jul;52(7):669-675 PMID: 36251932

Narges K Gortany, .et al. , Cancer Chemother Pharmacol, 2021, Mar 10 PMID: 33688998

Hamzehlou S, .et al. , Eur J Pharmacol, 2019, Nov 15;863:172705 PMID: 31574259

Hayato Ogura, .et al. , Sci Rep, 2017, 7: 5519 PMID: 28717217

Fuse MJ, .et al. , Mol Cancer Ther, 2017, Oct;16(10):2130-2143 PMID: 28751539

Ryohei Katayama, .et al. , Clin Cancer Res, 2015, Jan 1; 21(1): 166-174 PMID: 25351743

生物活性

Discription

Foretinib (GSK1363089), a multikinase inhibitor of c-Met and VEGFR-2, blocks proliferation, induces Anoikis, and impairs ovarian cancer metastasis.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10998
分子式	C34H34F2N4O6
分子量	632.7
CAS号	849217-64-7
SMILES	COC1=CC2=C(C=CN=C2C=C1OCCCN3CCOCC3)OC4=C(C=C(C=C4)NC(=O)C5(CC5)C(=O)NC6=CC=C(C=C6)F)F
其他名称	GSK089, EXEL-2880
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	87 mg/mL (137.51 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% propylene glycol, 5% Tween 80, 65% D5W	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.81 mL	79.03 mL	158.05 mL
0.5 mM	3.16 mL	15.81 mL	31.61 mL
1 mM	1.58 mL	7.9 mL	15.81 mL
5 mM	0.32 mL	1.58 mL	3.16 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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