FRAX597

Name: FRAX597
SKU: A12553
Price: 175 CNY
Rating: 5 (1 reviews)

目录号: A12553

PAK 抑制剂

1 篇发表文献

FRAX597 是一种小分子吡啶并嘧啶酮，是一种强效且与 ATP 竞争的 group I PAKs 抑制剂（PAK1 IC50= 8 nM，PAK2 IC50= 13 nM，PAK3 IC50= 19 nM）。

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Grouped product items
规格	价格	库存
1mg	¥175.00	现货
2mg	¥280.00	现货
5mg	¥525.00	现货
10mg	¥910.00	现货
25mg	¥1,715.00	现货
50mg	¥2,870.00	现货
100mg	¥4,270.00	现货
500mg	¥9,275.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用FRAX597发表的1篇文献

Dongdong Fang, etc. Epithelial-Mesenchymal Transition of Ovarian Cancer Cells Is Sustained by Rac1 through Simultaneous Activation of MEK1/2 and Src Signaling Pathways. Oncogene. 2017 Mar; 36(11): 1546?€?1558.

生物活性

Discription

FRAX597, a small-molecule pyridopyrimidinone, is a potent and ATP competitive inhibitor of the group I PAKs (PAK1 IC50= 8 nM, PAK2 IC50= 13 nM, PAK3 IC50= 19 nM).

Targets

Target	Value

产品信息

目录号	A12553
分子式	C29H28ClN7OS
分子量	558.1
CAS号	1286739-19-2
SMILES	CCN1C2=NC(=NC=C2C=C(C1=O)C3=C(C=C(C=C3)C4=CN=CS4)Cl)NC5=CC=C(C=C5)N6CCN(CC6)C
其他名称	FRAX 597, FRAX-597
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	Warmed: 13 mg/mL (23.29 mM)
	Water	Insoluble
	Ethanol	1 mg/mL (1.79 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17.92 mL	89.59 mL	179.18 mL
0.5 mM	3.58 mL	17.92 mL	35.84 mL
1 mM	1.79 mL	8.96 mL	17.92 mL
5 mM	0.36 mL	1.79 mL	3.58 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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