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Fulvestrant是一种雌激素受体拮抗剂，没有激动剂作用，它通过下调和降解雌激素受体发挥作用。
靶点信息
| ER (Cell-free assay) | ||||
| 0.94 nM |
| In vitro (25°C) | DMSO | 88 mg/mL (145.02 mM) | |
| Water | Insoluble | ||
| Ethanol | Warmed: 88 mg/mL (145.02 mM) | ||
| In vivo | 2% DMSO+30% PEG 300+2% Tween 80+ddH2O | 0.3 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.48 mL | 82.4 mL | 164.8 mL |
| 0.5 mM | 3.3 mL | 16.48 mL | 32.96 mL |
| 1 mM | 1.65 mL | 8.24 mL | 16.48 mL |
| 5 mM | 0.33 mL | 1.65 mL | 3.3 mL |
*The above data is based on the productmolecular weight 606.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10410 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 606.8 |
| Formula | C32H47F5O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 129453-61-8 |
| Synonyms | ICI 182,780 ; ICI 182780 ; ICI182780 |
| SMILES | C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)[C@@H](CC4=C3C=CC(=C4)O)CCCCCCCCCS(=O)CCCC(C(F)(F)F)(F)F |
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