FzM1.8

Name: FzM1.8
SKU: A18760
Price: 210 CNY
Rating: 5 (288 reviews)

目录号: A18760

FZD4 agonist

FzM1.8 是 Frizzled 受体 FZD4 的一种变构激动剂，具有 pEC50 值为 6.4。FzM1.8 与 FZD4 结合，并在没有任何 WNT 配体的情况下激活 WNT/β-catenin 通路，通过促进 TCF/LEF 的转录活性。FzM1.8 的结合增强了 FZD4 对异源三聚体 G 蛋白的亲和力，并刺激释放 Gβγ 亚基，进而激活 PI3K。

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Grouped product items
规格	价格	库存
1mg	¥210.00	现货
5mg	¥420.00	现货
10mg	¥700.00	现货
25mg	¥1,540.00	现货
50mg	¥2,555.00	现货
100mg	¥4,025.00	现货
*10mM 1mL in DMSO**	¥630.00	现货
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Data Sheet

SDS

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生物活性

Discription	FzM1.8 is an allosteric agonist of the Frizzled receptor FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 binding stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K.

产品信息

目录号	A18760
分子式	C18H14N2O4
分子量	322.32
CAS号	2204290-85-5
SMILES	O=C(O)C1=CC(NC(NC2=CC=C3C=CC=CC3=C2)=O)=CC(O)=C1
其他名称	FzM1.8; FzM-1.8; FzM 1.8
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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