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FzM1.8

FzM1.8

Name: FzM1.8
SKU: A18760

目录号: A18760

FZD4 agonist

FzM1.8 Chemical Structure

CAS NO. 2204290-85-5

FzM1.8 is an allosteric agonist of the Frizzled receptor FZD4 with pEC50 of 6.4. FzM1.8 binds to FZD4 and activates the WNT/β-catenin pathway, by promoting TCF/LEF transcriptional activity in the absence of any WNT ligand. FzM1.8 binding stabilizes FZD4 with an increased affinity for heterotrimeric G protein and stimulates the release of the Gβγ subunit that in turn activates PI3K.

库存：现货

规格	价格	数量
5 mg	￥ 2,450.00
10 mg	￥ 4,550.00
50 mg	￥ 14,000.00

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制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	31.03 mL	155.13 mL	310.25 mL
0.5 mM	6.21 mL	31.03 mL	62.05 mL
1 mM	3.1 mL	15.51 mL	31.03 mL
5 mM	0.62 mL	3.1 mL	6.21 mL

*The above data is based on the productmolecular weight 322.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A18760
作用机制	Agonist (激动剂)
M. Wt	322.32
Formula	C18H14N2O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	2204290-85-5
Synonyms	FzM1.8; FzM-1.8; FzM 1.8
SMILES	O=C(O)C1=CC(NC(NC2=CC=C3C=CC=CC3=C2)=O)=CC(O)=C1