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GDC-0349是一种有效的，选择性的，ATP竞争性的mTOR抑制剂，Ki为3.8 nM，比作用于PI3Kα和其他266种激酶的抑制效果高790倍。
靶点信息
| mTOR | PI3Kα | |||
| 3.8 nM(Ki) | ~3 μM(Ki) |
| In vitro | DMSO | 79 mg/mL (174.56 mM) | |
| Water | Insoluble | ||
| Ethanol | 5 mg/mL (11.04 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.09 mL | 110.47 mL | 220.95 mL |
| 0.5 mM | 4.42 mL | 22.09 mL | 44.19 mL |
| 1 mM | 2.21 mL | 11.05 mL | 22.09 mL |
| 5 mM | 0.44 mL | 2.21 mL | 4.42 mL |
*The above data is based on the productmolecular weight 452.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11443 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 452.6 |
| Formula | C24H32N6O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1207360-89-1 |
| Synonyms | GDC 0349, RG7603 |
| SMILES | CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(CCN(C3)C4COC4)C(=N2)N5CCOC[C@@H]5C |
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