GDC-0449 (Vismodegib)

Name: GDC-0449 (Vismodegib)
SKU: A10258

目录号: A10258

Hedgehog 拮抗剂

Product Citations (3)

GDC-0449 (Vismodegib) Chemical Structure

CAS NO. 879085-55-9

GDC-0449 (Vismodegib)是一种新型有效的，特异性hedgehog抑制剂，IC50为3 nM。

库存：现货

规格	价格	数量
25 mg	￥ 350.00
50 mg	￥ 420.00
200 mg	￥ 770.00
10mM * 1mL in DMSO	￥ 350.00

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生物活性

GDC-0449 (Vismodegib)是一种新型有效的，特异性hedgehog抑制剂，IC50为3 nM。

溶解度 *

In vitro (25°C)	DMSO	72 mg/mL (170.9 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O	11.8 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.74 mL	118.68 mL	237.36 mL
0.5 mM	4.75 mL	23.74 mL	47.47 mL
1 mM	2.37 mL	11.87 mL	23.74 mL
5 mM	0.47 mL	2.37 mL	4.75 mL

*The above data is based on the productmolecular weight 421.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10258
作用机制	Antagonist (拮抗剂)
M. Wt	421.3
Formula	C19H14Cl2N2O3S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	879085-55-9
SMILES	ClC1=C(C=C(NC(C2=CC=C(S(C)(=O)=O)C=C2Cl)=O)C=C1)C3=NC=CC=C3