GDC-0449 (Vismodegib)

Name: GDC-0449 (Vismodegib)
SKU: A10258
Price: 210 CNY
Rating: 5 (6 reviews)

目录号: A10258

Hedgehog 拮抗剂

6 篇发表文献

GDC-0449（Vismodegib）是一种新型、特异性的合成口服刺猬通路抑制剂，其IC50为3 nM，具有更高的效力。

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Grouped product items
规格	价格	库存
5mg	¥210.00	现货
10mg	¥245.00	现货
25mg	¥280.00	现货
50mg	¥350.00	现货
100mg	¥525.00	现货
200mg	¥700.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用GDC-0449 (Vismodegib)发表的6篇文献

Yichuan You, .et al. , J Hazard Mater, 2023, Oct 15:460:132489 PMID: 37688871

Yan Guo, .et al. , Differentiation, 2023, May-Jun;131:82-88 PMID: 37178555

Mucahit Varli, .et al. , Sci Rep, 2023, Feb 16;13(1):2811 PMID: 36797277

Daniel Doheny, .et al. , Oncogene, 2020, Oct;39(42):6589-6605 PMID: 32929154

Yi Yang, .et al. , Molecules, 2018, Nov; 23(11): 2968 PMID: 30441806

Olesen UH, .et al. , Lasers Surg Med, 2018, Aug 28 PMID: 30152536

生物活性

Discription

GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10258
分子式	C19H14Cl2N2O3S
分子量	421.3
CAS号	879085-55-9
SMILES	ClC1=C(C=C(NC(C2=CC=C(S(C)(=O)=O)C=C2Cl)=O)C=C1)C3=NC=CC=C3
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	72 mg/mL (170.9 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5% DMSO+40% PEG 300+5% Tween 80+50% ddH2O	11.8 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.74 mL	118.68 mL	237.36 mL
0.5 mM	4.75 mL	23.74 mL	47.47 mL
1 mM	2.37 mL	11.87 mL	23.74 mL
5 mM	0.47 mL	2.37 mL	4.75 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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