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GDC-0980 (Apitolisib, RG7422)

GDC-0980 (Apitolisib, RG7422)

Name: GDC-0980 (Apitolisib, RG7422)
SKU: A11023

目录号: A11023

mTOR/PI3K 抑制剂

Product Citations (1)

GDC-0980 (Apitolisib, RG7422) Chemical Structure

CAS NO. 1032754-93-0

GDC-0980 (Apitolisib,RG7422)是一种有效的，I型PI3激酶和mTOR激酶抑制剂（TORC1/2），对于p110α，β，δ和γ的体外IC50为5、27、7和14 nM。

库存：现货

规格	价格	数量
5 mg	￥ 420.00
10 mg	￥ 700.00
50 mg	￥ 1,820.00
100 mg	￥ 3,080.00
10mM * 1mL in DMSO	￥ 525.00

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生物活性

GDC-0980 (Apitolisib,RG7422)是一种有效的，I型PI3激酶和mTOR激酶抑制剂（TORC1/2），对于p110α，β，δ和γ的体外IC50为5、27、7和14 nM。

靶点信息

p110α (Cell-free assay)	p110δ (Cell-free assay)	p110γ (Cell-free assay)	mTOR (Cell-free assay)	p110β (Cell-free assay)
5 nM	7 nM	14 nM	17 nM(Ki app)	27 nM

溶解度 *

In vitro (25°C)	DMSO	20 mg/mL (40.11 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% methylcellulose+0.2% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	20.06 mL	100.28 mL	200.56 mL
0.5 mM	4.01 mL	20.06 mL	40.11 mL
1 mM	2.01 mL	10.03 mL	20.06 mL
5 mM	0.4 mL	2.01 mL	4.01 mL

*The above data is based on the productmolecular weight 498.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11023
作用机制	Inhibitor (抑制剂)
M. Wt	498.6
Formula	C23H30N8O3S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1032754-93-0
Synonyms	GDC0980
SMILES	CC1=C(SC2=C1N=C(N=C2N3CCOCC3)C4=CN=C(N=C4)N)CN5CCN(CC5)C(=O)[C@H](C)O