GDC046
目录号: A22299
TYK2 抑制剂
GDC046(化合物3)是一种强效、选择性且口服生物利用度高的TYK2抑制剂,其Ki值分别为4.8 nM(针对TYK2)、83.8 nM(针对JAK1)、27.6 nM(针对JAK2)和253 nM(针对JAK3)。
Discription | GDC046 (Compound 3) is a potent, selective, and orally bioavailable inhibitor of TYK2 with Ki of 4.8 nM, 83.8 nM, 27.6 nM and 253 nM for TYK2, JAK1, JAK2, and JAK3, respectively. | |||||
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Cell Research |
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目录号 | A22299 |
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分子式 | C16H13Cl2N3O2 |
分子量 | 350.2 |
CAS号 | 1258292-64-6 |
SMILES | O=C(NC1=CC(NC(C2CC2)=O)=NC=C1)C3=C(Cl)C=CC=C3Cl |
其他名称 | GDC-046,GDC 046 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2