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GDC0994 (Ravoxertinib)

GDC0994 (Ravoxertinib)

Name: GDC0994 (Ravoxertinib)
SKU: A13420

目录号: A13420

ERK1/2 抑制剂

GDC0994 (Ravoxertinib) Chemical Structure

CAS NO. 1453848-26-4

GDC-0994是一种强效选择性Erk1/2抑制剂。GDC-0994抑制ERK磷酸化和ERK介导的信号转导通路的激活。

库存：现货

规格	价格	数量
5 mg	￥ 560.00
10 mg	￥ 700.00
25 mg	￥ 1,330.00
10mM * 1mL in DMSO	￥ 595.00

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生物活性

GDC-0994是一种强效选择性Erk1/2抑制剂。GDC-0994抑制ERK磷酸化和ERK介导的信号转导通路的激活。

靶点信息

ERK2	ERK1
0.3 nM	1.1 nM

溶解度 *

In vitro (25°C)	DMSO	83 mg/mL (188.7 mM)
	Water	Insoluble
	Ethanol	83 mg/mL
In vivo	2% DMSO+30% PEG 300+5% Tween 80+ddH2O	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.68 mL	113.41 mL	226.82 mL
0.5 mM	4.54 mL	22.68 mL	45.36 mL
1 mM	2.27 mL	11.34 mL	22.68 mL
5 mM	0.45 mL	2.27 mL	4.54 mL

*The above data is based on the productmolecular weight 440.87. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A13420
作用机制	Inhibitor (抑制剂)
M. Wt	440.87
Formula	C21H18ClFN6O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1453848-26-4
Synonyms	GDC-0994
SMILES	CN1C(=CC=N1)NC2=NC=CC(=N2)C3=CC(=O)N(C=C3)[C@H](CO)C4=CC(=C(C=C4)Cl)F