Gefapixant
目录号: A19254
P2X3R antagonist
Gefapixant 是一种口服活性的 P2X3 受体 (P2X3R) 拮抗剂，其 IC50 值针对重组的 hP2X3 同三聚体约为 30 nM，而在 hP2X2/3 异三聚体受体上为 100-250 nM。
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生物活性
| Discription | Gefapixant is an orally active P2X3 receptor (P2X3R) antagonist with IC50s of ~30 nM versus recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors. |
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产品信息
| 目录号 | A19254 |
|---|---|
| 分子式 | C14H19N5O4S |
| 分子量 | 353.4 |
| CAS号 | 1015787-98-0 |
| SMILES | O=S(C1=CC(OC2=CN=C(N)N=C2N)=C(C(C)C)C=C1OC)(N)=O |
| 其他名称 | AF219, AF 219, AF-219; MK-7264, MK7264, MK 7264 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 65 mg/mL (183.92 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.3 mL | 141.48 mL | 282.97 mL |
| 0.5 mM | 5.66 mL | 28.3 mL | 56.59 mL |
| 1 mM | 2.83 mL | 14.15 mL | 28.3 mL |
| 5 mM | 0.57 mL | 2.83 mL | 5.66 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 1015787-98-0 | 1015787-98-0 供应商 | 1015787-98-0 花费 | 1015787-98-0 生产商 | 订购 1015787-98-0 | 1015787-98-0 代理商