Gefitinib-based PROTAC 3

Name: Gefitinib-based PROTAC 3
SKU: A19093
Price: 210 CNY
Rating: 5 (288 reviews)

目录号: A19093

基于吉非替尼的PROTAC 3，通过连接体将EGFR结合元素与VHL配体连接，分别在HCC827（外显子19缺失）和H3255（L858R突变）细胞中诱导EGFR降解，其DC50s分别为11.7 nM和22.3 nM。

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规格	价格	库存
2mg	¥210.00	现货
5mg	¥350.00	现货
10mg	¥665.00	现货
25mg	¥1,190.00	现货
50mg	¥1,855.00	现货
100mg	¥2,695.00	现货
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Data Sheet

SDS

Other Forms of Gefitinib-based PROTAC 3

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生物活性

Discription

Gefitinib-based PROTAC 3, conjugating an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827(exon 19 del) and H3255 (L858R mutantion) cells, respectively.

Targets

Target	Value

产品信息

目录号	A19093
分子式	C47H57ClFN7O8S
分子量	934.51
CAS号	2230821-27-7
SMILES	O=C([C@H]1N(C([C@@H](NC(CCOCCOCCCCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2OC)=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	92 mg/mL (98.44 mM)
	Water	Insoluble
	Ethanol	92 mg/mL (98.44 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	10.7 mL	53.5 mL	107.01 mL
0.5 mM	2.14 mL	10.7 mL	21.4 mL
1 mM	1.07 mL	5.35 mL	10.7 mL
5 mM	0.21 mL	1.07 mL	2.14 mL

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