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GF 109203X

目录号: A13197
PKC 抑制剂
GF 109203X 是一种强效且选择性的 蛋白激酶C 抑制剂,特别选择性地针对 αβ1 亚型(IC50 值分别为 0.0084、0.0180、0.210、0.132 和 5.8 μM,针对 αβ1δεζ 亚型)。相较于 MLCK、PKG 和 PKA 具有选择性(IC50 值分别为 0.6、4.6 和 33 μM)。在 5-HT3 受体上是一种强效拮抗剂(Ki = 29.5 nM)。
Grouped product items
规格 价格 库存 数量
5mg
¥385.00
现货
10mg
¥665.00
现货
25mg
¥1,330.00
现货
50mg
¥2,520.00
现货
100mg
¥3,395.00
现货
10mM * 1mL in DMSO
¥700.00
现货
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重要通知:仅供研究使用。我们不向患者销售。

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生物活性
Discription GF 109203X is a potent and selective inhibitor of protein kinase C, selective for the α and β1 isoforms (IC50 values are 0.0084, 0.0180, 0.210, 0.132, and 5.8 μM for α, β1, δ, ε and ζ isoforms respectively). Selective over MLCK, PKG and PKA (IC50 values are 0.6, 4.6, and 33 μM respectively). Potent antagonist at the 5-HT3 receptor (Ki = 29.5 nM).
Targets
Target Value
Cell Research
Cell Line Type Value Description References
产品信息
目录号 A13197
分子式 C25H24N4O2
分子量 412.49
CAS号 133052-90-1
SMILES CN(C)CCCN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54
其他名称 GF-109203X, GF109203X, GO6850, GO-6850, Bisindolylmaleimide I
储存条件

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据
In vitro DMSO 70 mg/mL (169.7 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 24.24 mL 121.22 mL 242.43 mL
0.5 mM 4.85 mL 24.24 mL 48.49 mL
1 mM 2.42 mL 12.12 mL 24.24 mL
5 mM 0.48 mL 2.42 mL 4.85 mL
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

  • Mass

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    Volume

    Molecular Weight

Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

  • C1

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    C2

    V2

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