Glimepiride
目录号: A10430
Kir6.2/SUR 抑制剂
格列美脲是一种强效的Kir6.2/SUR抑制剂，其IC50分别为SUR1的3.0 nM、SUR2A的5.4 nM和SUR2B的7.3 nM，用于治疗2型糖尿病。
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生物活性
| Discription | Glimepiride is a potent Kir6.2/SUR inhibitor with IC50 of 3.0 nM, 5.4 nM, and 7.3 nM for SUR1, SUR2A and SUR2B, used in the treatment of type 2 diabetes mellitus. | ||
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| Targets |
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产品信息
| 目录号 | A10430 |
|---|---|
| 分子式 | C24H34N4O5S |
| 分子量 | 490.62 |
| CAS号 | 93479-97-1 |
| SMILES | CCC1=C(CN(C1=O)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCC(CC3)C)C |
| 其他名称 | Amary |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 10 mg/mL (20.38 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.38 mL | 101.91 mL | 203.82 mL |
| 0.5 mM | 4.08 mL | 20.38 mL | 40.76 mL |
| 1 mM | 2.04 mL | 10.19 mL | 20.38 mL |
| 5 mM | 0.41 mL | 2.04 mL | 4.08 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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