Glycine

Name: Glycine
SKU: A17936
Price: 245 CNY
Rating: 5 (288 reviews)

目录号: A17936

NMDA antagonist

AZD-4282，也被称为氨基乙酸和甘氨酸，是一种N-甲基-D-天冬氨酸（NMDA）受体拮抗剂，可能用于治疗神经病性疼痛。

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Data Sheet

SDS

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生物活性

Discription

AZD-4282, also known as aminoacetic acid and glycine, is a N-methyl-D-aspartate (NMDA) receptor antagonist potentially for the treatment of neuropathic pain.

Targets

Cell Research

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Cell Line	Type	Value	Description	References
HEK293	EC50	106 μM	Substrate uptake and inhibition of the Glycine Transporter-1 (GlyT1, SLC6A9) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC6A9 cells	10.5281/zenodo.7361399
HEK293	EC50	128 μM	Substrate uptake by the Glycine Transporter-2 (GlyT2, SLC6A5) as assessed by the fluorescent FLIPR membrane potential dye in HEK-293 JumpIN-SLC6A5 cells	10.5281/zenodo.7360571
HEK293	EC50	94 μM	Antagonist activity at human glycine alpha-1 receptor in HEK293 cells by FMP assay	[PMID: 17722904]
KB 3-1	IC50	> 50 mM	Cytotoxicity against human KB-3-1 cells incubated for 72 hrs by MTT assay	[PMID: 21657271]
KB-V1	IC50	> 50 mM	Cytotoxicity against drug-resistant human KBV1 cells expressing P-gp incubated for 72 hrs by MTT assay	[PMID: 21657271]

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产品信息

目录号	A17936
分子式	C2H5NO2
分子量	75.07
CAS号	56-40-6
SMILES	O=C(O)CN
其他名称	AZD-4282; AZD 4282; AZD4282; Aminoacetic acid; glycine
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	Insoluble
	Water	14 mg/mL (186.49 mM)
	* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	133.21 mL	666.05 mL	1332.09 mL
0.5 mM	26.64 mL	133.21 mL	266.42 mL
1 mM	13.32 mL	66.6 mL	133.21 mL
5 mM	2.66 mL	13.32 mL	26.64 mL

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