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GNE-207 is a novel, potent, and orally bioavailable inhibitor of the bromodomain of CBP. GNE-207 has excellent CBP potency (CBP IC50?=?1?nM, MYC EC50?=?18?nM), and it exhibits a good pharmacokinetic profile.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.58 mL | 97.92 mL | 195.85 mL |
| 0.5 mM | 3.92 mL | 19.58 mL | 39.17 mL |
| 1 mM | 1.96 mL | 9.79 mL | 19.58 mL |
| 5 mM | 0.39 mL | 1.96 mL | 3.92 mL |
*The above data is based on the productmolecular weight 510.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18844 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 510.6 |
| Formula | C29H30N6O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2158266-58-9 |
| Synonyms | GNE207, GNE 207 |
| SMILES | O=C(NC)C1=NC=C(C2=CC3=C(C=N2)C(C4=NN(C5CCOCC5)C6=C4CN(C(C)=O)CC6)=CC=C3)C=C1 |
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