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GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.35 mL | 116.77 mL | 233.54 mL |
| 0.5 mM | 4.67 mL | 23.35 mL | 46.71 mL |
| 1 mM | 2.34 mL | 11.68 mL | 23.35 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.67 mL |
*The above data is based on the productmolecular weight 428.2. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20295 |
|---|---|
| M. Wt | 428.2 |
| Formula | C17H10Cl2F3N5O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 2026635-66-3 |
| Synonyms | GNE-5729; GNE5729 |
| SMILES | ClC1=C([C@H]2[C@H](C#N)C2)N3C(C=C1)=NC(CN4N=C(C(F)(F)F)C=C4Cl)=CC3=O |
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