GNE-781
目录号: A19798
CBP 抑制剂
GNE-781 是一种高效且选择性的 CBP 抑制剂，在 TR-FRET 测试中的 IC50 为 0.94 nM。GNE-781 还能抑制 BRET 和 BRD4(1)，其 IC50 分别为 6.2 nM 和 5100 nM。
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生物活性
| Discription | GNE-781 is a highly potent and selective CBP inhibitor with an IC50 of 0.94 nM in TR-FRET assay. GNE-781 also inhibits BRET and BRD4(1) with IC50s of 6.2 nM and 5100 nM, respectively. | |||||
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| Cell Research |
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产品信息
| 目录号 | A19798 |
|---|---|
| 分子式 | C27H33F2N7O2 |
| 分子量 | 525.59 |
| CAS号 | 1936422-33-1 |
| SMILES | O=C(N1CCC(N(C2CCOCC2)N=C3N4CCCC5=C4C=C(C(F)F)C(C6=CN(C)N=C6)=C5)=C3C1)NC |
| 其他名称 | GNE 781; GNE781 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 96 mg/mL (182.65 mM) | |
| Water | Insoluble | ||
| Ethanol | 96 mg/mL | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.03 mL | 95.13 mL | 190.26 mL |
| 0.5 mM | 3.81 mL | 19.03 mL | 38.05 mL |
| 1 mM | 1.9 mL | 9.51 mL | 19.03 mL |
| 5 mM | 0.38 mL | 1.9 mL | 3.81 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 1936422-33-1 | 1936422-33-1 供应商 | 1936422-33-1 花费 | 1936422-33-1 生产商 | 订购 1936422-33-1 | 1936422-33-1 代理商