产品详情

生物活性

GNF-7是一种有效的II型激酶Bcr-Abl抑制剂，对于M351T，T315I，E255 V，G250E和c-Abl，IC50分别<5 nM，61 nM，122 nM，136 nM和133 nM。

靶点信息

M351T	T315I	E255V	c-Abl	G250E
<5 nM	61 nM	122 nM	133 nM	136 nM

溶解度 *

In vitro	DMSO	17 mg/mL (31.04 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.26 mL	91.32 mL	182.64 mL
0.5 mM	3.65 mL	18.26 mL	36.53 mL
1 mM	1.83 mL	9.13 mL	18.26 mL
5 mM	0.37 mL	1.83 mL	3.65 mL

*The above data is based on the productmolecular weight 547.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A15887
作用机制	Inhibitor (抑制剂)
M. Wt	547.53
Formula	C28H24F3N7O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	839706-07-9
Synonyms	GNF7, GNF 7
SMILES	O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=CC=C(C)N=C4)N=C3N(C)C2=O)=C1)C5=CC=CC(C(F)(F)F)=C5